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The latter has been identified as the enzyme tissue transglutaminase which belongs to a family of enzymes that catalyze protein cross\u2010linking reactions and is constitutively expressed in many tissues as well as being activated during apoptosis. In a recent paper, we described the selection and characterization of anti\u2010transglutaminase Igs from phage antibody libraries created from intestinal lymphocytes from celiac disease patients. In this work, using transglutaminase gene fragments, we identify a region of tissue transglutaminase recognized by these antibodies as being conformational and located in the core domain of the enzyme. This is identical to the region recognized by anti\u2010transglutaminase Igs found in the serum of celiac disease patients.<\/jats:p>","DOI":"10.1046\/j.1432-1033.2002.03215.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:35:51Z","timestamp":1047407751000},"page":"5175-5181","source":"Crossref","is-referenced-by-count":49,"title":["The analysis of the fine specificity of celiac disease antibodies using tissue transglutaminase fragments"],"prefix":"10.1111","volume":"269","author":[{"given":"Daniele","family":"Sblattero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorella","family":"Florian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Azzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevin","family":"Zyla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Baldas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarcisio","family":"Not","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Bradbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Marzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,17]]},"reference":[{"key":"e_1_2_18_2_2","first-page":"S2","article-title":"Celiac disease and other nutrient related injuries to the gastrointestinal tract","volume":"89","author":"Goggins M.","year":"1994","journal-title":"Am. 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