{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:37:56Z","timestamp":1767854276162,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":603,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Reproductive management programmes based on strategic use of prostaglandin F<jats:sub>2\u03b1<\/jats:sub> (PGF<jats:sub>2\u03b1<\/jats:sub>) to induce and synchronize oestrus in post\u2010partum dairy cows are widespread. Repeated shortening of the oestrous cycle during early lactation in high\u2010yielding dairy cows, however, could impair corpus luteum function and thus decrease fertility. The objective of this study was to analyse the effect of repeated treatments with the prostaglandin F<jats:sub>2\u03b1<\/jats:sub> analogue D (+) cloprostenol sodium on progesterone concentrations indicative of a functional corpus luteum in post\u2010partum dairy cows. Furthermore, the influence of milk production, parity and endometritis on progesterone concentrations under these circumstances were studied. Eighty\u2010four cows of a commercial dairy operation were treated three to four times with D (+) cloprostenol sodium (Preloban\u00ae Hoechst Roussel Vet, Wiesbaden, Germany) at 14\u2010day intervals, starting 22\u201328 days post\u2010partum. Blood samples were collected prior to treatment 1 (sample 1) and 14 days after treatments 1, 2 and 3 (samples 2\u20134) and serum progesterone (P4) levels were determined. The percentage of cows with P4 levels &lt; 1 ng\/ml decreased from 51 % in sample 1 to 23 % in samples 3 and 4. More primiparous cows had low P4 levels 14 days after the second treatment than older cows (<jats:italic>P<\/jats:italic> &lt; 0.05). Cows with low progesterone levels in sample 3 or 4 had lower protein contents in milk on the second milk test day post\u2010partum and in their cumulative milk yield of the first 100 days of lactation. Clinical endometritis at post\u2010partum examination did not influence progesterone levels after treatment with PGF<jats:sub>2\u03b1<\/jats:sub>. Repeated application of PGF<jats:sub>2\u03b1<\/jats:sub> (more than twice) in the post\u2010partum period does not influence serum progesterone levels 14 days after treatment. Failure to develop luteal tissue after treatment contributed to the conception failures after first service.<\/jats:p>","DOI":"10.1046\/j.1439-0442.2000.00281.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:10:09Z","timestamp":1047460209000},"page":"213-220","source":"Crossref","is-referenced-by-count":14,"title":["Serum Progesterone Levels in Post\u2010Partum Dairy Cows after Repeated Application of the Prostaglandin F<sub>2\u03b1<\/sub> Analogue D (+) Cloprostenol Sodium"],"prefix":"10.1111","volume":"47","author":[{"given":"B.\u2010A.","family":"Tenhagen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Birkelbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Heuwieser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,16]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Adams G. P. 1998:Control of ovarian follicular wave dynamics in mature and prepubertal cattle for synchronization and superstimulation. In:Caple I.(ed.) Proc. XXth World Association for Buiatrics Congress Sydney Australia 6\u201310 July 1998 595605.Australian Association of Cattle Veterinarians Indooroopilly Australia."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(94)77216-7"},{"key":"e_1_2_6_4_1","unstructured":"Bergmann J. 1998:Energy balance in post\u2010partum dairy cows: Impacts on the pituitary reaction on a single GnRH administration and on different metabolic indicators.PhD Thesis Free University of Berlin Fac. Vet. Med. Berlin."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0540447"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(82)82242-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(92)77964-8"},{"key":"e_1_2_6_8_1","first-page":"1081","article-title":"Use of prostaglandin F2\u03b1 in the treatment of unobserved estrus in lactating dairy cattle","volume":"44","author":"Elmarimi A. A.","year":"1983","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","unstructured":"J\u00f6chle W.&D. R.Lamond 1980:Control of Reproductive Functions in Domestic Animals.Gustav Fischer\u2010Verlag Jena Germany.","DOI":"10.1007\/978-94-017-1173-9"},{"key":"e_1_2_6_10_1","first-page":"477","article-title":"Physiological effects of undernutrition on post\u2010partum anoestrus in cows","volume":"49","author":"Jolly P. D.","year":"1995","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/clinchem\/30.2.284","article-title":"Evaluation of a direct solid\u2010phase radioimmunoassay for progesterone, useful for monitoring luteal function","volume":"30","author":"Kubasik N. P.","year":"1984","journal-title":"Clin. Chem."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(86)80652-X"},{"issue":"5","key":"e_1_2_6_13_1","first-page":"104","article-title":"Effects of a simple prostaglandin program on the reproductive performance of large dairy herds and the economic success of a dairy enterprise. A field trial","volume":"33","author":"Mansfeld R.","year":"1998","journal-title":"Reprod. Dom. Anim."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(84)81312-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(90)78968-0"},{"issue":"5","key":"e_1_2_6_16_1","first-page":"23","article-title":"Differences of corpus luteum function in cyclic and early pregnant cows","volume":"33","author":"Schneebeli J.","year":"1998","journal-title":"Reprod. Dom. Anim."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1357729800014260"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(90)78750-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(87)90044-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.1999.00205.x"},{"key":"e_1_2_6_21_1","unstructured":"Tischer M. 1998:Comparison of three management programs to improve reproductive efficiency in dairy herds. Effect of intrauterine treatment and prostaglandin F2\u03b1in cows with endometritis.PhD Thesis Free University of Berlin Fac. Vet. Med. 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