{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:10:53Z","timestamp":1784308253084,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2002,12,14]],"date-time":"2002-12-14T00:00:00Z","timestamp":1039824000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This report describes the gross, histopathological, immunohistochemical and electron microscopic findings in a 4\u2010year\u2010old cat with systemic <jats:italic>Cryptococcus neoformans<\/jats:italic> infection. A 1\u2010cm diameter pontine mass, pinpoint lesions in the cerebellum and in the right kidney were the main macroscopic findings. A presumptive diagnosis of cerebral neoplasia with metastasis was formulated. Light microscopy revealed a huge number of yeasts surrounded by a pyogranulomatous inflammatory reaction in the cerebral parenchyma and, to a lesser extent, in the kidney, while the meninges were not involved. The positive mucicarmine stain that coloured the capsule of the yeasts was indicative of cryptococcal infection. Immunohistochemistry confirmed the presence of <jats:italic>C. neoformans<\/jats:italic> var. <jats:italic>grubii<\/jats:italic> (<jats:italic>C. neoformans<\/jats:italic> serotype A). Electron microscopy revealed yeasts with a massive fibrillar capsule and lamellar cell wall free in the cerebral tissue and within macrophages.<\/jats:p>","DOI":"10.1046\/j.1439-0442.2002.00501.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:11:30Z","timestamp":1047460290000},"page":"526-530","source":"Crossref","is-referenced-by-count":14,"title":["Central Nervous System Cryptococcoma in a Cat"],"prefix":"10.1111","volume":"49","author":[{"given":"L.","family":"Mandrioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bettini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Marcato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Benazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Della Salda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Krockenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. E.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2000.tb10581.x"},{"key":"e_1_2_5_3_1","first-page":"71","article-title":"Systemic cryptococcosis in a cat","volume":"61","author":"Berry W. L.","year":"1990","journal-title":"J. S. Afr. Vet. Assoc."},{"key":"e_1_2_5_4_1","first-page":"88","article-title":"Cryptococcosis of the nervous system in dogs. Part 1: Epidemiologic, clinical, and neuropathologic features","author":"Berthelin C. F.","year":"1994","journal-title":"Prog. Vet. Neurol."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v70i1.748"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1995.tb00036.x"},{"key":"e_1_2_5_7_1","volume-title":"A Colour Atlas and Textbook of the Histopathology of Mycotic Diseases","author":"Chandler F. W.","year":"1980"},{"key":"e_1_2_5_8_1","first-page":"761","volume-title":"Ultrastructural Pathology","author":"Cheville N. F.","year":"1994"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1997.tb00194.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1128\/JCM.37.3.838-840.1999","article-title":"Cryptococcus neoformans var. grubii: separate varietal status for C. neoformans serotype A isolates","volume":"37","author":"Franzot S. P.","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-33-2-118"},{"key":"e_1_2_5_12_1","first-page":"141","article-title":"A cryptococcal granuloma in the brain of a cat causing focal signs","volume":"7","author":"Glass E.","year":"1996","journal-title":"Prog. Vet. Neurol."},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-280X.1998.00132.x"},{"key":"e_1_2_5_14_1","first-page":"295","volume":"3","author":"Kozel T. R.","year":"1995","journal-title":"Virulence factors of Cryptococcus neoformans. Trends Microbiol."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.39.6.523.533"},{"key":"e_1_2_5_16_1","first-page":"213","article-title":"High prevalence of Cryptococcus neoformans var. gattii in tropical and subtropical regions","volume":"257","author":"Kwong\u2010Chung K. J.","year":"1984","journal-title":"Zentralbl. Bakteriol. Mikrobiol. Hyg. A"},{"key":"e_1_2_5_17_1","volume-title":"Manual of histological staining methods of the Armed Forces Institute of Pathology","author":"Luna L. G.","year":"1968"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681219280000181"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681219280000321"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.9.3365-3367.2001"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.515"},{"key":"e_1_2_5_22_1","first-page":"57","article-title":"Liver pathology in cats naturally and experimentally infected by feline immunodeficiency virus","volume":"6","author":"Poli A.","year":"2000","journal-title":"Eur. J. Vet. Pathol."},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)80025-2"},{"key":"e_1_2_5_24_1","volume-title":"Atlas of Fungal Pathology","author":"Salfelder K.","year":"1990"},{"key":"e_1_2_5_25_1","first-page":"379","volume-title":"Infectious Diseases","author":"Samuelson S.","year":"1999"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(94)00063-C"},{"key":"e_1_2_5_27_1","volume-title":"Veterinary Neuropathology","author":"Summers B. A.","year":"1995"}],"container-title":["Journal of Veterinary Medicine Series A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1439-0442.2002.00501.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1439-0442.2002.00501.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T10:39:35Z","timestamp":1697193575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1439-0442.2002.00501.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1046\/j.1439-0442.2002.00501.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1439-0442.2002.00501.x","archive":["Portico"],"relation":{},"ISSN":["0931-184X"],"issn-type":[{"value":"0931-184X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}