{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:31:16Z","timestamp":1789039876794,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,6,13]],"date-time":"2003-06-13T00:00:00Z","timestamp":1055462400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study was designed to investigate the effects <jats:italic>Nigella sativa<\/jats:italic> L. (NS) and <jats:italic>Urtica dioica<\/jats:italic> L. (UD) on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010treated rats. A total of 60 healthy male Sprague\u2013Dawley rats were utilized in this study. The rats were randomly allotted into one of four experimental groups: A (CCl<jats:sub>4<\/jats:sub>\u2010only treated), B (CCl<jats:sub>4<\/jats:sub>\u2003+\u2003UD treated), C (CCl<jats:sub>4<\/jats:sub>\u2003+\u2003NS treated) and D (CCl<jats:sub>4<\/jats:sub>\u2003+\u2003UD\u2003+\u2003NS treated), each containing 15 animals. All groups received CCl<jats:sub>4<\/jats:sub> [0.8\u2003ml\/kg of body weight, subcutaneously, twice a week for 90\u2003days starting day\u20031]. In addition, B, C and D groups also received daily intraperitoneal injections of 0.2\u2003ml\/kg NS or\/and 2\u2003ml\/kg UD oils for 45\u2003days starting day\u200346. Group A, on the other hand, received only 2\u2003ml\/kg normal saline solution for 45\u2003days starting day 46. Blood samples for the biochemical analysis were taken by cardiac puncture from five randomly chosen rats in each treatment group at beginning, at 45th and at 90th day of the experiment. The CCl<jats:sub>4<\/jats:sub> treatment for 45\u2003days increased the lipid peroxidation and liver enzymes, and also decreased the antioxidant enzyme levels. NS or UD treatments (alone or combination) for 45\u2003days starting day\u200346 decreased the elevated lipid peroxidation and liver enzyme levels and also increased the reduced antioxidant enzyme levels. Live weights of the rats decreased in group A, and increased in groups B, C and D. It is concluded that NS and UD decrease the lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in the CCl<jats:sub>4<\/jats:sub>\u2010treated rats.<\/jats:p>","DOI":"10.1046\/j.1439-0442.2003.00537.x","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T05:26:39Z","timestamp":1104125199000},"page":"264-268","source":"Crossref","is-referenced-by-count":81,"title":["Effects of <i>Nigella sativa<\/i> L. and <i>Urtica dioica<\/i> L. on Lipid Peroxidation, Antioxidant Enzyme Systems and Some Liver Enzymes in CCl<sub>4<\/sub>\u2010Treated Rats"],"prefix":"10.1111","volume":"50","author":[{"given":"M.","family":"Kanter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Meral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cemek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ozbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Uygan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Gunduz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,13]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"281","article-title":"The physiological role of zinc as an antioxidant. 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