{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:28:27Z","timestamp":1761661707467},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":542,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine, Series B"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To investigate the influence of antibiotics used as feed additives on the immune response to erysipelas live vaccine, the pig inoculation test was applied. Avilamycin, oxytetracycline quaternary salt, enramycin, virginiamycin and tylosin phosphate were selected as test antibiotics. Five experimental feeds containing each antibiotic at the highest concentration permitted for feed additives in Japan, and the basal diet lacking antibiotics were examined. Twenty\u2010nine pigs were divided into six groups. At first all the groups were fed with the antibiotic\u2010free basal diet for 7 days, and then each group received the experimental feeds. On the 14th day after feeding with test feeds all the pigs, except for one control pig in each group, were immunized with the vaccine and all the pigs were then challenge\u2010exposed to a virulent strain of <jats:italic>Erysipelothrix rhusiopathiae<\/jats:italic> 14 days after vaccination. The clinical response was observed every day for 14 days. In all the groups, most of the vaccinated pigs did not develop any clinical signs of acute erysipelas after the challenge exposure, whereas non\u2010vaccinated control pigs died or showed severe generalized erythema with profound depression and anorexia. No differences in the protection against the challenge exposure were observed among the groups. Therefore, the present results suggest that these selected antibiotics would not interfere with the immune effect of the vaccine if given at the usual concentrations used for feed additives.<\/jats:p>","DOI":"10.1046\/j.1439-0450.2000.00366.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:13:16Z","timestamp":1047460396000},"page":"453-460","source":"Crossref","is-referenced-by-count":7,"title":["Influence of Antibiotics Used as Feed Additives on the Immune Effect of Erysipelas Live Vaccine in Swine"],"prefix":"10.1111","volume":"47","author":[{"given":"K.","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.S.","family":"Endoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804272981708"},{"key":"e_1_2_6_3_1","first-page":"365","article-title":"Erysipeloid und septishe Rotlauf\u2010komplikation","volume":"107","author":"Ewald F. W.","year":"1965","journal-title":"Muench. Med. Wochenschr."},{"key":"e_1_2_6_4_1","first-page":"98","volume-title":"On the standardization of the method for determination of minimum inhibitory concentrations","author":"Ishiyama S.","year":"1968"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/59.2.219"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms1939.41.593"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms1939.33.161"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197307000-00008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(89)90029-1"}],"container-title":["Journal of Veterinary Medicine, Series B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1439-0450.2000.00366.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1439-0450.2000.00366.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T08:29:07Z","timestamp":1698568147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1439-0450.2000.00366.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1046\/j.1439-0450.2000.00366.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1439-0450.2000.00366.x","archive":["Portico"],"relation":{},"ISSN":["0931-1793"],"issn-type":[{"value":"0931-1793","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}