{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:10:58Z","timestamp":1698642658190},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":542,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine, Series B"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In this study, macroscopic and histopathological lesions produced by a virulent South American isolate (\u2018Quillota\u2019) of hog cholera virus were studied. The virus was inoculated in doses of 10<jats:sup>5<\/jats:sup> TCID<jats:sub>50<\/jats:sub> in each of 35 pigs of 20 kg live weight. The animals were slaughtered from 4 to 18 days post\u2010inoculation. The presence of virus antigens in lymphatic tissue was confirmed by both direct immunofluorescence and Avidin\u2010Biotin\u2010Peroxidase techniques in formalin\u2010embedded tissue samples. Histological sections were stained with haematoxylin\u2010eosin and Mallory's phosphotungstic acid haematoxylin methods. The \u2018Quillota\u2019 isolate used in this study caused a disease characterized by vascular lesions (splenic infarcts, haemorrhages in the lymph nodes and the urinary system and disseminated microthrombosis), and necrosis of lymphocytes, particularly in the B\u2010areas of the lymphoid organs, lesions that are characteristic of the acute form of the disease. Other lesions observed were a non\u2010purulent meningoencephalitis, the necrosis of the epithelial cells of tonsils, the presence of fibrin nets in the red pulp and a marked thickening of the alveolar septa.<\/jats:p>","DOI":"10.1046\/j.1439-0450.2000.00376.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:13:16Z","timestamp":1047460396000},"page":"411-422","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of Lesions Caused by a South American Virulent Isolate (\u2018Quillota\u2019) of the Hog Cholera Virus"],"prefix":"10.1111","volume":"47","author":[{"given":"M.","family":"Quezada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Islas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lecocq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"G\u00f3mez\u2010Villamandos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"29","volume-title":"Curso de Perfeccionamiento. Actualizaci\u00f3n en Patolog\u00eda Porcina","author":"Adriazola A.","year":"1994"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300606"},{"key":"e_1_2_6_4_1","first-page":"93","article-title":"Development of microscopic lesions in splenic cords of pigs infected with African swine fever virus","volume":"28","author":"Carrasco L.","year":"1997","journal-title":"Vet. Res."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(96)90062-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(97)90190-9"},{"key":"e_1_2_6_7_1","first-page":"261","article-title":"The pathogenesis of chronic hog cholera (swine fever). Histologic, immunofuorescent and electron microscopic studies","volume":"20","author":"Cheville N. F.","year":"1969","journal-title":"Lab. Invest."},{"key":"e_1_2_6_8_1","first-page":"458","article-title":"Ultrastructural and immunofluorescent studies of glomerulonephritis in chronic hog cholera","volume":"22","author":"Cheville N. F.","year":"1970","journal-title":"Lab. Invest."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(92)90093-7"},{"key":"e_1_2_6_10_1","volume-title":"Disease of Swine","author":"Dunne H. W.","year":"1975"},{"key":"e_1_2_6_11_1","first-page":"615","article-title":"The pathogenesis of hog cholera. I. Route of the virus into the animal's body","volume":"20","author":"Dunne H. W.","year":"1959","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_6_12_1","first-page":"2414","article-title":"Coagulation changes in African swine fever virus infection","volume":"45","author":"Edwards W. J.","year":"1984","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(05)80081-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(95)90049-7"},{"key":"e_1_2_6_15_1","first-page":"179","article-title":"Experimental infection of weaner pigs with a field isolate of hog cholera\/classical swine fever virus derived from a recent outbreak in Lower Saxony. II: pathological findings","volume":"82","author":"Gruber A.","year":"1995","journal-title":"Wien. Tier\u00e4rztl. Mschr."},{"key":"e_1_2_6_16_1","first-page":"139","article-title":"Pathogenesis and epidemiology of hog cholera","volume":"18","author":"Liess B.","year":"1987","journal-title":"Ann. Rech. Vet."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063879700900103"},{"key":"e_1_2_6_18_1","first-page":"409","article-title":"Pathogenesis of hog cholera: host response","volume":"30","author":"Mengeling W.","year":"1969","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(92)90094-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1973.tb01126.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589503200404"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1128\/jvi.66.2.1171-1175.1992","article-title":"Pathogenesis of classical swine fever: B\u2010lymphocytes deficiency caused by hog cholera virus","volume":"66","author":"Susa M.","year":"1992","journal-title":"J. Virol."},{"key":"e_1_2_6_23_1","first-page":"72","volume-title":"African Swine Fever","author":"Terpstra C.","year":"1987"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1935(91)90081-W"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2083-8_2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1981.tb01743.x"},{"key":"e_1_2_6_27_1","unstructured":"VanOirschot J. T. 1980:Persistent and Inapparent Infections with Swine Fever Virus of Low Virulence. Their Effects on the Immune System 126128.PhD: ThesisUniversity of Utrecht."},{"key":"e_1_2_6_28_1","first-page":"113","volume-title":"Virus Infections of Porcines","author":"Oirschot J. T.","year":"1989"},{"key":"e_1_2_6_29_1","first-page":"1956","article-title":"Hog cholera in gnobiotic pigs. Clinical signs and gross pathological findings in germ\u2010free and monocontaminated pigs","volume":"140","author":"Weide K. D.","year":"1962","journal-title":"J. Am. Vet. Med. Ass."}],"container-title":["Journal of Veterinary Medicine, Series B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1439-0450.2000.00376.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1439-0450.2000.00376.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T08:28:44Z","timestamp":1698568124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1439-0450.2000.00376.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1046\/j.1439-0450.2000.00376.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1439-0450.2000.00376.x","archive":["Portico"],"relation":{},"ISSN":["0931-1793"],"issn-type":[{"value":"0931-1793","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}