{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T07:19:08Z","timestamp":1715411948455},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T00:00:00Z","timestamp":1253145600000},"content-version":"vor","delay-in-days":3242,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine, Series B"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To study the phenomenon of host adaptation in <jats:italic>Salmonella<\/jats:italic>, a mathematical model has been developed which permits a definition and experimental investigation of the specific interaction between the adapted serovar and the adequate host. After experimental infection using a mixture of equal parts of two <jats:italic>Salmonella<\/jats:italic> strains, A and B, the bacterial concentrations C<jats:sub>A<\/jats:sub> and C<jats:sub>B<\/jats:sub> were determined in the organs of the animals infected. If an animal of species a and an animal of species b are infected with the same mixture of strain A adapted to a and strain B adapted to b, an expression:<\/jats:p><jats:p>may be calculated which describes the influence of the specific serovar\u2010host interaction on the dynamics of the bacterial count. The variable Q<jats:sub>ab<\/jats:sub> was determined using four <jats:italic>Salmonella dublin<\/jats:italic>, four <jats:italic>Salmonella<\/jats:italic><jats:italic>choleraesuis<\/jats:italic> and five <jats:italic>Salmonella gallinarum\/pullorum<\/jats:italic> strains in a total of 63 pairs of different hosts (calf and pig, calf and chicken, or pig and chicken). On this basis, the following statements can be made. The epidemiologically defined host adaptation of Salmonellas is accompanied by a specific agent\u2010host interaction between the adapted serovar and adequate host. It promotes adherence and spreading of the agent in the adequate host. The effect was particularly expressed on day 3 post\u2010infection and could be detected both in the lumen of the anterior sections of the intestine and in the intestinal lymph nodes and the liver. In part, the host\u2010independent strain characteristics had a greater influence than the specific serovar\u2010host interaction on the dynamics of the bacterial count. Strains of non\u2010adapted serovars may thus result in a more intense colonization and invasion of the host than simultaneously administered bacteria of a serovar which is adapted to the respective host. The effects of a specific serovar\u2010host interaction on colonization of and spreading in the host should be considered only as a component which contributes to the phenomenon of host adaptation.<\/jats:p>","DOI":"10.1046\/j.1439-0450.2000.00403.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:13:58Z","timestamp":1047460438000},"page":"707-719","source":"Crossref","is-referenced-by-count":4,"title":["Studies of the Phenomenon of Host Adaptation in <i>Salmonella<\/i>"],"prefix":"10.1111","volume":"47","author":[{"given":"G.","family":"Steinbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lauterbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Methner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9,17]]},"container-title":["Journal of Veterinary Medicine, Series B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1439-0450.2000.00403.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1439-0450.2000.00403.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T08:39:34Z","timestamp":1698568774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1439-0450.2000.00403.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1046\/j.1439-0450.2000.00403.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1439-0450.2000.00403.x","archive":["Portico"],"relation":{},"ISSN":["0931-1793"],"issn-type":[{"value":"0931-1793","type":"print"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}