{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:56:14Z","timestamp":1790009774979,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2008,9,23]],"date-time":"2008-09-23T00:00:00Z","timestamp":1222128000000},"content-version":"vor","delay-in-days":2030,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2003,3,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of the study was to compare the efficacy and tolerability of flutrimazole 1% powder vs. bifonazole 1% powder in treating tinea pedis. A multicentre, double blind, randomized, parallel and comparative study was conducted. Two hundred and twenty\u2010two patients with clinically and mycologically confirmed tinea pedis were randomized to flutrimazole (<jats:italic>n<\/jats:italic>\u2003=\u2003136) or bifonazole (<jats:italic>n<\/jats:italic>\u2003=\u2003138) 1% powder applied twice daily for 4\u2003weeks. The corresponding clinical cure rates were assessed at 2 and 4\u2003weeks of treatment, and the global (clinical and mycological) cure rates were determined at the fourth week. Clinical cure rates were 83.5 and 82.4% for flutrimazole and bifonazole, respectively (95% CI: \u22120.0806 to 0.1009). Global cure rates were observed in 65.3 and 70.1% of patients treated with flutrimazole and bifonazole, respectively (95% CI: \u22120.0828 to 0.1779). Three non serious adverse events at the application site \u2010 itching (one patient per group) and dishydrotic eczema (one patient treated with flutrimazole) \u2013 were recorded during the study. These results support that flutrimazol 1% powder applied twice daily for a duration of 4\u2003weeks is highly effective in the treatment of tinea pedis, showing a similar therapeutic profile with that of bifonazole 1% powder.<\/jats:p>","DOI":"10.1046\/j.1439-0507.2003.00849.x","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T17:15:22Z","timestamp":1104167722000},"page":"126-131","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of flutrimazole 1% powder in the treatment of tinea pedis"],"prefix":"10.1111","volume":"46","author":[{"given":"J.","family":"Pereda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Noguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Boncompte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alguer\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Izquierdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Flutrimazole Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,23]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.9.3226-3230.2000"},{"key":"e_1_2_12_3_2","first-page":"2193","volume-title":"Dermatology in General Medicine","author":"Blake Goslen J","year":"1987"},{"key":"e_1_2_12_4_2","unstructured":"IzquierdoI Garc\u00eda\u2010RafanellJ.Flutrimazole.Drugs Fut1994;19(suppl 1):26\u201335."},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1994.tb00400.x"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246720"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1995.tb00071.x"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2000.00575.x"},{"key":"e_1_2_12_9_2","first-page":"836","article-title":"In vitro and in vivo activity studies with flutrimazole, a new imidazole derivative with antifungal activity","volume":"42","author":"Garc\u00eda\u2010Rafanell J","year":"1992","journal-title":"Arzneim Forsch Drug Res"},{"key":"e_1_2_12_10_2","first-page":"117","article-title":"vitro activity of flutrimazole against Candida species and other medically important yeasts","volume":"10","author":"Burgos A","year":"1993","journal-title":"Rev Iberoam Micol"},{"key":"e_1_2_12_11_2","first-page":"34","article-title":"Microdilution susceptibility for Candida, dermatophytes and moulds using flutrimazole and clotrimazole","volume":"4","author":"Carrillo\u2010Mu\u00f1oz AJ","year":"1994","journal-title":"J Micol Med"},{"key":"e_1_2_12_12_2","first-page":"832","article-title":"Synthesis and antifungal activity of a series of difluorotrityl\u2010imidazoles","volume":"42","author":"Bartrol\u00ed J","year":"1992","journal-title":"Arzneim Forsch Drug Res"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02263500"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198938020-00004"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1439-0507.2003.00849.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1439-0507.2003.00849.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T16:30:23Z","timestamp":1693413023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1439-0507.2003.00849.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,4]]},"references-count":13,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2003,3,4]]}},"alternative-id":["10.1046\/j.1439-0507.2003.00849.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1439-0507.2003.00849.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,4]]}}}