{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:59:53Z","timestamp":1765609193739},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":723,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust. N.Z. J. Surg."],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p> <jats:bold>Background<\/jats:bold>: The role of <jats:italic>Helicobacter pylori<\/jats:italic> infection in the development of Barrett\u2019s oesophagus and its complications is uncertain. The aim of the present study was to determine the importance of <jats:italic>H. pylori<\/jats:italic> infection in this disease by comparing the frequency of oesophageal and gastric <jats:italic>H. pylori<\/jats:italic> infection in a group of patients with Barrett\u2019s oesophagus or adenocarcinoma, with the frequency of infection in a control group without Barrett\u2019s disease.<\/jats:p><jats:p> <jats:bold>Methods<\/jats:bold>: The study group included 160 patients (123 male, 37 female; mean age: 61.2 years) who were classified (according to the highest grade pathological lesion in the oesophagus) as having Barrett\u2019s intestinal metaplasia (IM; 88 patients), Barrett\u2019s oesophagus with low\u2010grade dysplasia (LGD; 28 patients), high\u2010grade dysplasia (HGD; five patients), Barrett\u2019s indefinite for dysplasia (<jats:italic>n<\/jats:italic> = 4), and Barrett\u2019s adenocarcinoma (33 patients). A total of 91 of these patients had gastric antral specimens available for study. The control group consisted of 214 consecutive, prospectively enrolled symptomatic patients (122 male, 92 female; mean age: 57.2 years) who underwent upper gastrointestinal endoscopy and in whom Barrett\u2019s oesophagus or Barrett\u2019s adenocarcinoma was not found. A modified Warthin\u2013Starry method was used to detect <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><jats:p> <jats:bold>Results<\/jats:bold>: Oesophageal <jats:italic>H. pylori<\/jats:italic> infection was found in eight of 160 (5%) patients with Barrett\u2019s oesophagus or Barrett\u2019s adenocarcinoma. <jats:italic>Helicobacter pylori<\/jats:italic> organisms in the oesophagus were found only on non\u2010intestinalized cardiac or oxyntocardiac mucosa. All patients with oesophageal <jats:italic>H. pylori<\/jats:italic> infection and an antral biopsy available for study had antral <jats:italic>H. pylori<\/jats:italic> infection. Gastric antral <jats:italic>H. pylori<\/jats:italic> infection was significantly less prevalent in patients in the Barrett\u2019s study group (15\/91, 16.5%) than in the non\u2010Barrett\u2019s control group (67\/214, 31.3%; Fisher\u2019s exact test, <jats:italic>P<\/jats:italic> = 0.01). Patients from the control group with an endoscopic diagnosis of duodenal ulcer, gastric ulcer, gastritis, or duodenitis had a significantly higher prevalence of infection compared with the Barrett\u2019s group, but there was no difference in the infection prevalence in patients in the Barrett\u2019s group and patients with reflux oesophagitis, hiatal hernia, no endoscopic abnormality, or any other diagnosis.<\/jats:p><jats:p> <jats:bold>Conclusions<\/jats:bold>: Oesophageal <jats:italic>H. pylori<\/jats:italic> infection is uncommon in patients with Barrett\u2019s IM, dysplasia, or adenocarcinoma, and may be restricted to non\u2010intestinalized columnar epithelium. Gastric <jats:italic>H. pylori<\/jats:italic> infection may have a protective effect for the development of Barrett\u2019s oesophagus.<\/jats:p>","DOI":"10.1046\/j.1440-1622.2000.01737.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T02:43:02Z","timestamp":1047350582000},"page":"26-33","source":"Crossref","is-referenced-by-count":38,"title":["PREVALENCE OF <i>HELICOBACTER PYLORI<\/i> INFECTION IN 160 PATIENTS WITH BARRETT\u2019S OESOPHAGUS OR BARRETT\u2019S ADENOCARCINOMA"],"prefix":"10.1111","volume":"70","author":[{"given":"Reginald V. 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