{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:35:10Z","timestamp":1761057310534},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":723,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust. N.Z. J. Surg."],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p> <jats:bold>Background<\/jats:bold>: The aim of the present study was to investigate the role of potential clinical risk factors in the causation of peri\u2010operative stroke associated with carotid endarterectomy. With the change in carotid endarterectomy practice from the use of a shunt to high\u2010dose thiopental for cerebral protection (a previously undocumented method), it was essential to identify accurately the causes of all peri\u2010operative strokes.<\/jats:p><jats:p> <jats:bold>Methods<\/jats:bold>: A prospective audit was undertaken of 1000 carotid endarterectomies in which the causes and pathology of all peri\u2010operative strokes were documented. The roles of advanced age, female gender, hypertension, previous stroke, contralateral carotid stenosis &gt; 70%, and contralateral carotid occlusion as potential causes of peri\u2010operative stroke were defined. Results were statistically analysed using odds ratio and Fisher\u2019s exact test.<\/jats:p><jats:p> <jats:bold>Results<\/jats:bold>: None of the potential risk factors was statistically significant for peri\u2010operative stroke. Female gender was associated with a significant risk of peri\u2010operative stroke due to operative site thrombosis. Complications at the endarterectomy site were the commonest cause of stroke.<\/jats:p><jats:p> <jats:bold>Conclusions<\/jats:bold>: Prospective audit is a useful tool for identifying causes of peri\u2010operative stroke and indicating the need for modifications to surgical clinical management which might improve outcomes for carotid endarterectomy.<\/jats:p>","DOI":"10.1046\/j.1440-1622.2000.01743.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T02:43:02Z","timestamp":1047350582000},"page":"52-56","source":"Crossref","is-referenced-by-count":21,"title":["RISK FACTORS FOR PERI\u2010OPERATIVE STROKE COMPLICATING CAROTID ENDARTERECTOMY: SELECTIVE ANALYSIS OF A PROSPECTIVE AUDIT OF 1000 CONSECUTIVE OPERATIONS"],"prefix":"10.1111","volume":"70","author":[{"given":"J. E.","family":"Frawley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7122.1571"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(94)70049-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)80006-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70286-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250701"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)70152-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","unstructured":"HertzerNR O\u2019HaraPJ MaschaEJ KrajewskiLP SullivanTM BevenEG.Early outcome assessment for 2228 consecutive carotid endarterectomy procedures: The Cleveland Clinic experience from 1989 to 1995.J. Vasc. Surg.1997;26: 1\u201310.","DOI":"10.1016\/S0741-5214(97)70139-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.2.554"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90944-Z"},{"key":"e_1_2_6_11_2","first-page":"3255","article-title":"Prevention of stroke by antihypertensive drug treatment in older persons with isolated hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP).","volume":"2654","author":"SHEP Co\u2010operative Research Group.","year":"1991","journal-title":"JAMA"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92916-P"},{"key":"e_1_2_6_13_2","first-page":"455","article-title":"Computerised audit of carotid endarterectomy: Audit loopholes closed?","volume":"79","author":"Lewis DR","year":"1997","journal-title":"Ann. R. Coll. Surg. Engl."}],"container-title":["Australian and New Zealand Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1622.2000.01743.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1622.2000.01743.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T20:16:59Z","timestamp":1698783419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1622.2000.01743.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1046\/j.1440-1622.2000.01743.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1622.2000.01743.x","archive":["Portico"],"relation":{},"ISSN":["0004-8682"],"issn-type":[{"value":"0004-8682","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}