{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:55:53Z","timestamp":1760781353947},"reference-count":31,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>1. A dietary combination of high salt and low potassium (HSLK) exacerbates hypertension in Dahl salt\u2010sensitive (DS) rats and renders previously normotensive Dahl salt\u2010resistant (DR) rats hypertensive. In both strains, the severity of hypertension correlates with urinary calcium loss. However, the magnitude of excretory calcium losses is significantly greater in DS rats and is potentiated by chemical sympathectomy in both strains.<\/jats:p><jats:p>2. We hypothesized that a defect in vitamin D metabolism may underlie the observed strain\u2010dependent differences in calcium balance.<\/jats:p><jats:p>3. Arterial blood pressure (ABP), water and mineral bal\u2010 ance and serum concentrations of 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> (1,25(OH)<jats:sub>2<\/jats:sub> D<jats:sub>3<\/jats:sub>) and 25\u2010hydroxyvitamin D<jats:sub>3<\/jats:sub> (25(OH)D<jats:sub>3<\/jats:sub>) were measured in intact and chemically sympathectomized (6\u2010hydroxydopamine; 6\u2010OHDA) DS and DR rats after 8 weeks on a HSLK diet.<\/jats:p><jats:p>4. Chronic ingestion of this diet resulted in marked and moderate levels of hypertension in DS and DR rats, respectively. The hypertension was abated and eliminated by 6\u2010OHDA in the DS and DR strains, respectively. Independent of treatment, DS rats had significantly higher urinary excretion of calcium and reduced intestinal absorption of the ion compared with DR rats. The DS rats had significantly higher serum levels of 1,25(OH)<jats:sub>2<\/jats:sub> D<jats:sub>3<\/jats:sub> and markedly lower serum levels of 25(OH)D<jats:sub>3<\/jats:sub> than DR rats. Chemical sympathectomy tended to increase 1,25(OH)<jats:sub>2<\/jats:sub> D<jats:sub>3<\/jats:sub> and to decrease 25(OH)D<jats:sub>3<\/jats:sub> levels in both strains.<\/jats:p><jats:p>5. These data indicate a genetic difference in vitamin D metabolism between DS and DR rats. The abnormally elevated levels of 1,25(OH)<jats:sub>2<\/jats:sub> D<jats:sub>3<\/jats:sub> in DS rats may be an appropriate compensatory response to excessive excretory calcium loss and reduced target organ sensitivity to the hormone and may, maladaptively, directly contribute to hypertension, by stimulating vascular smooth muscle contractility.<\/jats:p>","DOI":"10.1046\/j.1440-1681.2000.03250.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T11:06:32Z","timestamp":1047380792000},"page":"378-383","source":"Crossref","is-referenced-by-count":14,"title":["Regulation Of Sodium, Calcium And Vitamin D Metabolism In Dahl Rats On A High\u2010Salt\/Low\u2010Potassium Diet: Genetic And Neural Influences"],"prefix":"10.1111","volume":"27","author":[{"given":"Xiaoyan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Milojevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Sonnenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis G","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.2.318"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-161-40483"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.12.6.562"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1983.220"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.123"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641969509033647"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641969809052120"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.23.4.513"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641969509037408"},{"key":"e_1_2_6_11_2","first-page":"191","article-title":"Mechanisms and regulation of calcium transport in the nephron.","volume":"13","author":"Bourdeau JE.","year":"1993","journal-title":"Semin. 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