{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:44:30Z","timestamp":1695977070368},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":466,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2000,9,14]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>1. To clarify the mechanism of the cardioprotective effect of nicorandil (2\u2010nicotinamidoethyl\u2010nitrate ester), the effects of nicorandil and nitric oxide (NO) donors on the release of ATP, ADP, AMP and adenosine from arterial segments and cultured endothelial cells of the porcine coronary artery were examined.<\/jats:p><jats:p>2. Nicorandil significantly increased the release of total adenyl purines from arterial segments and from cultured endothelial cells.<\/jats:p><jats:p>3. Cromakalim, an ATP\u2010sensitive K<jats:sup>+<\/jats:sup> channel opener, did not affect the release of total adenyl purines from coronary artery segments.<\/jats:p><jats:p>4. <jats:sc>S<\/jats:sc>\u2010Nitroso\u2010<jats:italic>N<\/jats:italic>\u2010acetyl\u2010\n\t\t\t\t\t<jats:sc>D<\/jats:sc>,\n\t\t\t\t\t<jats:sc>L<\/jats:sc>\u2010penicillamine and isosorbide dinitrate, NO donors, significantly increased the release of total adenyl purines from coronary artery segments.<\/jats:p><jats:p>5. These results demonstrate that nicorandil stimulates ATP release from the coronary artery by acting not as an ATP\u2010sensitive K<jats:sup>+<\/jats:sup> channel opener, but as a nitrate, thus suggesting the cardioprotective properties of nicorandil.<\/jats:p>","DOI":"10.1046\/j.1440-1681.2000.03319.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T11:08:06Z","timestamp":1047380886000},"page":"680-683","source":"Crossref","is-referenced-by-count":0,"title":["Nicorandil Stimulates Release Of Adenyl Purines From Porcine Coronary Artery"],"prefix":"10.1111","volume":"27","author":[{"given":"Tetsuya","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishi","family":"Nosaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhei","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Masumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90200-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","unstructured":"GrossGJ AuchampachJA MaruyamaM WarltierDC PieperGM.Cardioprotective effects of nicorandil.J. 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