{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:12:54Z","timestamp":1779894774058,"version":"3.53.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":428,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2000,10,22]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>1. Although much is known of signalling events associated with angiogenesis, starting with a sprout, less is known of how an intact microvascular network is correctly formed following the initiation of sprouting. The aim of the present report is to evaluate some of the factors that could be involved in directing the patterning of the resulting microvascular bed.<\/jats:p><jats:p>2. Hypothetical \u2018patterning rules\u2019 are discussed and considered in the context of data obtained from studies of angiogenesis. The guidelines suggest that both tissue\u2010 and stimulus\u2010specific regulators are involved in directing patterning.<\/jats:p><jats:p>3. Examples of \u2018patterned\u2019 and \u2018non\u2010patterned\u2019 angiogenesis in rat mesentery are given, with evidence to support stimulus\u2010related differences in angiogenesis patterns.<\/jats:p><jats:p>4. Skeletal muscle angiogenesis follows metabolic patterns within the muscle, as discerned through traditional histochemical evaluation. However, further examination, using confocal microscopy and new patterning assays, indicates that branching patterns differ according to stimulus. Patterning guidelines within the tissue may be important in preventing the growth of sinusoidal vessels.<\/jats:p><jats:p>5. The concept of \u2018angiotypes\u2019 is proposed to direct future studies towards understanding how therapeutic angiogenesis or angiostasis applications can be used to obtain correctly patterned microvascular networks. Angiogenesis via \u2018branching\u2019 compared with \u2018non\u2010branching\u2019 angiotypes will involve different signalling pathways. Both sprouting and dividing of capillaries are found in the \u2018branching\u2019 angiotype, with each pattern having several subtypes that would be expected to be mediated via different signalling mechanisms.<\/jats:p>","DOI":"10.1046\/j.1440-1681.2000.03341.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T11:04:47Z","timestamp":1047380687000},"page":"830-835","source":"Crossref","is-referenced-by-count":39,"title":["Capillary Network Patterning During Angiogenesis"],"prefix":"10.1111","volume":"27","author":[{"given":"Fay M","family":"Hansen\u2010Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70333-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-9896(199904)187:5<503::aid-path279>3.0.co;2-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1357-4310(96)10048-4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81810-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80108-7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80137-3"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050681"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.2.324"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.55.Suppl_65"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744262"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051121"},{"key":"e_1_2_6_13_2","first-page":"9","article-title":"MCF\u201010A cells infected with the int\u20102 oncogene induce angiogenesis in the chick chorioallantoic membrane and in the rat mesentery.","volume":"54","author":"Costa M","year":"1994","journal-title":"Cancer Res."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1994.1029"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","unstructured":"Hansen\u2010SmithF&MorrisL.Patterns of physiological angiogenesis in adult mesentery. In: Maragoudakis ME (ed.).Angiogenesis: Models Modulators and Clinical Applications.Plenum Press New York. 1998; 75\u201384.","DOI":"10.1007\/978-1-4757-9185-3_9"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","unstructured":"NorrbyK.Basic fibroblast growth factor andde novomammalian angiogenesis.Microvasc. Res.1994.;48: 96\u2013113.","DOI":"10.1006\/mvre.1994.1041"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000178833"},{"key":"e_1_2_6_18_2","first-page":"1","article-title":"Capillary growth in the mesentery of normal young rats. Intravital video and electron microscope analyses.","volume":"21","author":"Rhodin J","year":"1989","journal-title":"J. Submicrosc. Cytol. Pathol."},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.1998.tb00079.x"},{"key":"e_1_2_6_20_2","unstructured":"NaitoJ MorrisL Hansen\u2010SmithF.Is local TGF\u03b2 modulated during angiotensin II\u2010induced angiogenesis?Microcirculation1996;3: 100 (Abstract)."},{"key":"e_1_2_6_21_2","unstructured":"ZweifachBW.Functional Behavior of the Microcirculation.Charles C Thomas Springfield IN. 1961."},{"key":"e_1_2_6_22_2","unstructured":"Hansen\u2010SmithF MarshickJ LynnL MorrisL.Does neutralization of bFGF alter microvascular network patterning in spontaneously angiogenic mesenteric windows? In: Maragoudakis ME (ed.).Angiogenesis: Models Modulators and Clinical Applications.Plenum Press New York. 1998; 524\u20135."},{"key":"e_1_2_6_23_2","unstructured":"Hansen\u2010SmithF HaasE LudwigK MorrisL.Angiogenesis in intact microvessel networks.Exp. Biol.1999;13: 18 (Abstract)."},{"key":"e_1_2_6_24_2","first-page":"166","article-title":"Increased stem cell factor release by hemangioma\u2010derived endothelial cells.","volume":"72","author":"Meininger C","year":"1995","journal-title":"Lab. Invest."},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.2.369"},{"key":"e_1_2_6_26_2","first-page":"H344","article-title":"Postnatal changes in capillary density of rat sternomastoid muscle.","volume":"257","author":"Hansen\u2010Smith F","year":"1989","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_27_2","doi-asserted-by":"crossref","unstructured":"VrbovaG GordonT JonesR.Nerve\u2013Muscle Interaction. Chapman & Hall London. 1978.","DOI":"10.1007\/978-94-010-9541-9"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","unstructured":"LindermanJ KloehnM GreeneA.Development of an implantable muscle stimulator: Measurement of stimulated angiogenesis and poststimulus vessel regression.Microcirculation2000;7: 119\u201328.","DOI":"10.1080\/sj.mn.7300100"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0185(199809)252:1<49::aid-ar6>3.0.co;2-9"},{"key":"e_1_2_6_30_2","unstructured":"Hansen\u2010SmithFM HudlickaO EggintonM.Muscle capillary branching patterns elicited during physiological angiogenesis vary qualitatively and quantitatively depending on stimulus.FASEB J.2000;14: A33."},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.15.6.779"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.15.6.922"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.17.6.902"},{"key":"e_1_2_6_34_2","unstructured":"Hansen\u2010SmithF LombardJH DeBruinJ GreeneA.Angiogenesis following rarefaction in cremaster muscle of reduced renal mass hypertensive rats.Exp. Biol.1999;13: 17 (Abstract)."}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1681.2000.03341.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1681.2000.03341.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T09:03:20Z","timestamp":1698570200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1681.2000.03341.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10,22]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10,22]]}},"alternative-id":["10.1046\/j.1440-1681.2000.03341.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1681.2000.03341.x","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10,22]]}}}