{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:08:02Z","timestamp":1758924482271},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,20]],"date-time":"2001-12-20T00:00:00Z","timestamp":1008806400000},"content-version":"vor","delay-in-days":290,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2001,3,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>1. The effects of diabetes on the electrical and contractile function of skeletal muscle are variable, depending on muscle fibre type distribution. The muscles of the upper airway have a characteristic fibre distribution that differs from previously studied muscles, but the effects of diabetes on upper airway muscle function are unknown. Normally, contraction of upper airway muscles, such as the sternohyoids, dilates and\/or stabilizes the upper airway, thereby preventing its collapse. Diabetes is associated with obstructive sleep apnoea in which there is collapse of the upper airway due to failure of the upper airway musculature to maintain airway patency. Therefore, the purpose of the present study was to determine the effects of diabetes on the electrical and contractile characteristics of upper airway muscle.<\/jats:p><jats:p>2. Rats were treated with vehicle (sodium citrate buffer; pH 4.5) or with streptozotocin to induce diabetes, confirmed by the presence of hyperglycaemia, and the contractile and electrical properties of the sternohyoid were compared in these two groups. Isometric contractile properties and membrane potentials were determined in isolated sternohyoid muscles in physiological saline solution at 25\u00b0C.<\/jats:p><jats:p>3. Streptozotocin had no effect on sternohyoid muscle fatigue, the tension\u2013frequency relationship or membrane potentials, but did increase contraction time, half\u2010relaxation time, twitch tension and tetanic tension.<\/jats:p><jats:p>4. Streptozotocin\u2010induced diabetes has no effect on sternohyoid muscle fatigue or the tension\u2013frequency relationship, but does reduce contractile kinetics and increases force generation. These effects are not due to changes in resting membrane potential. These data are evidence that the association of sleep apnoea and diabetes is not due to effects on upper airway muscle contractile properties.<\/jats:p>","DOI":"10.1046\/j.1440-1681.2001.03433.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T11:09:36Z","timestamp":1047380976000},"page":"184-187","source":"Crossref","is-referenced-by-count":20,"title":["Contractile And Electrical Properties Of Sternohyoid Muscle In Streptozotocin Diabetic Rats"],"prefix":"10.1111","volume":"28","author":[{"given":"M","family":"McGuire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dumbleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"MacDermott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bradford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-4598(199601)19:1<2::aid-mus1>3.0.co;2-j"},{"key":"e_1_2_6_3_2","first-page":"73","article-title":"Diffuse muscle fiber atrophy in newly diagnosed diabetes.","volume":"5","author":"Jakobsen J","year":"1986","journal-title":"Clin. 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