{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:35:06Z","timestamp":1697610906513},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":175,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2001,7,21]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>1. The aim of the present study was to investigate the effects of <jats:sc>L<\/jats:sc>\u2010arginine (<jats:sc>L<\/jats:sc>\u2010Arg) on blood pressure and water and electrolyte excretion in control and extracellular fluid volume\u2010expanded rats (10% bodyweight with 0.9% NaCl) and to determine whether diuretic treatment with furosemide (FUR) can be optimized by the administration of <jats:sc>L<\/jats:sc>\u2010Arg in this model.<\/jats:p><jats:p>2. Both groups of animals were anaesthetized, divided into groups and treated with either 7.5 mg\/kg FUR, 250 mg\/kg <jats:sc>L<\/jats:sc>\u2010Arg, 1 mg\/kg <jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine methyl ester (<jats:sc>L<\/jats:sc>\u2010NAME), FUR + <jats:sc>L<\/jats:sc>\u2010NAME or FUR + <jats:sc>L<\/jats:sc>\u2010Arg. Mean arterial pressure (MAP), diuresis, natriuresis and kaliuresis were determined.<\/jats:p><jats:p>3. Extracellular fluid volume expansion induced no changes in MAP in control and volume\u2010expanded rats (92\u00b16 <jats:italic>vs<\/jats:italic> 100\u00b18 mmHg, respectively). The hypotension induced by FUR in control and volume\u2010expanded rats (69\u00b17 and 76\u00b15 mmHg, respectively) was significantly (<jats:italic>P<\/jats:italic> &lt; 0.01) enhanced by the administration of <jats:sc>L<\/jats:sc>\u2010Arg (54\u00b13 and 64\u00b13 mmHg, respectively).<\/jats:p><jats:p>4. Injection of <jats:sc>L<\/jats:sc>\u2010NAME increased MAP and diminished diuresis, natriuresis and kaliuresis in both groups.<\/jats:p><jats:p>5. Furosemide\u2010induced water and electrolyte excretion was blunted by the administration of <jats:sc>L<\/jats:sc>\u2010NAME.<\/jats:p><jats:p>6. The combination of <jats:sc>L<\/jats:sc>\u2010Arg + FUR increased diuresis induced by FUR alone (control rats: 29.33\u00b11.68 <jats:italic>vs<\/jats:italic> 12.91\u00b1 0.41 \u03bcL\/min per 100 g, respectively; volume\u2010expanded rats: 248.5\u00b125.4 <jats:italic>vs<\/jats:italic> 112,6\u00b18.3 \u03bcL\/min per 100 g, respectively; <jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><jats:p>7. The administration of the combination of <jats:sc>L<\/jats:sc>\u2010Arg + FUR promoted a decrease in the sodium\/water excretion ratio compared with the administration of FUR alone (control rats: 0.230\u00b10.018 <jats:italic>vs<\/jats:italic> 0.45\u00b10.03, respectively, <jats:italic>P<\/jats:italic> &lt; 0.001; volume\u2010expanded rats: 0.091\u00b10.010 <jats:italic>vs<\/jats:italic> 0.22\u00b10.03, respectively, <jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><jats:p>8. The potassium\/water excretion rate induced by FUR alone and in the presence of <jats:sc>L<\/jats:sc>\u2010Arg followed a pattern similar to that seen for natriuresis (control rats: 0.35\u00b10.05 <jats:italic>vs<\/jats:italic> 0.20\u00b10.05 \u03bcEq\/min per 100 g, respectively; volume\u2010expanded rats: 0.045\u00b10.008 <jats:italic>vs<\/jats:italic> 0.014\u00b10.003 \u03bcEq\/min per 100 g, respectively; <jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><jats:p>9. The decrease in the electrolyte\/water excretion ratio observed with FUR + <jats:sc>L<\/jats:sc>\u2010Arg in volume\u2010expanded rats was greater than in control animals.<\/jats:p><jats:p>10. The results of the present study show that the administration of FUR with <jats:sc>L<\/jats:sc>\u2010Arg contributes to enhanced hypotensive and diuretic effects of FUR, thus diminishing the relative electrolyte excretion in normal conditions and in extracellular fluid volume expansion.<\/jats:p>","DOI":"10.1046\/j.1440-1681.2001.03482.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T11:10:27Z","timestamp":1047381027000},"page":"528-532","source":"Crossref","is-referenced-by-count":8,"title":["Effects Of <scp>L<\/scp>\u2010Arginine And Furosemide On Blood Pressure And Renal Function In Volume\u2010Expanded Rats"],"prefix":"10.1111","volume":"28","author":[{"given":"Ma","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am","family":"Balaszczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ct","family":"Arranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,12]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"109","article-title":"Nitric oxide: Physiology, pathophysiology, and pharmacology.","volume":"43","author":"Moncada S","year":"1991","journal-title":"Pharmacol. 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