{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:46:23Z","timestamp":1791294383570,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>Dendritic cells (DC) are the major antigen\u2010presenting cells in the induction of cellular responses to intracellular pathogens, such as mycobacteria. Recent studies have shown that they also play a critical role in the regulation of immune responses. The interaction of DC with microbial antigens may be the controlling factor in the development of a Th1\u2010orientated protective immunity. Analysis of the innate response of DC to mycobacteria and the involvement of the DC receptors in antigen recognition have highlighted the pivotal role of these cells in T\u2010cell activation. Mycobacteria\u2010infected DC have an enhanced capacity to release pro\u2010inflammatory cytokines and chemokines and are potent inducers of interferon\u2010\u03b3\u2010producing cells <jats:italic>in vivo<\/jats:italic>. Therefore, DC manipulation for maximal antigen presentation and Th1 cytokine production may form the basis of a new generation of vaccines, with improved efficacy against mycobacterial infections.<\/jats:p>","DOI":"10.1046\/j.1440-1711.2000.00935.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:42:15Z","timestamp":1047429735000},"page":"318-324","source":"Crossref","is-referenced-by-count":79,"title":["Interaction of dendritic cells with mycobacteria: Where the action starts"],"prefix":"10.1111","volume":"78","author":[{"given":"Caroline","family":"Demangel","sequence":"first","affiliation":[{"name":"Centenary Institute of Cancer Medicine and Cell Biology  New South Wales Australia"},{"name":"Institut Pasteur, Laboratoire d\u2019Ingenierie des Anticorps  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick J","family":"Britton","sequence":"additional","affiliation":[{"name":"Centenary Institute of Cancer Medicine and Cell Biology  New South Wales Australia"},{"name":"University of Sydney, Department of Medicine  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80153-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80066-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.11.1819"},{"key":"e_1_2_7_6_1","first-page":"423","article-title":"The role of interleukin\u201012 in acquired immunity to Mycobacterium tuberculosis infection.","volume":"84","author":"Cooper AM","year":"1995","journal-title":"Immunology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2243"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(93)90066-Y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.59.4.505"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.6.1693"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.83"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4049\/jimmunol.159.2.635","article-title":"Activation of human dendritic cells following infection with Mycobacterium tuberculosis.","volume":"159","author":"Henderson RA","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<1972::AID-IMMU1972>3.0.CO;2-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970106)70:1<128::AID-IJC19>3.0.CO;2-H"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.4049\/jimmunol.162.3.1851","article-title":"CD1 expression by dendritic cells in human leprosy lesions: Correlation with effective host immunity.","volume":"162","author":"Sieling PA","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.297"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.4049\/jimmunol.161.7.3582","article-title":"Down\u2010regulation of CD1 on antigen\u2010presenting cells by infection with Mycobacterium tuberculosis.","volume":"161","author":"Stenger S","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0966-842X(94)90005-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.1.39"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00193.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.11.4843-4849.1997"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5243"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1997.d01-380.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.389"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.4049\/jimmunol.163.6.3029","article-title":"Human dendritic cells very efficiently present a heterologous antigen expressed on the surface of recombinant gram\u2010positive bacteria to CD4 (+) T lymphocytes.","volume":"163","author":"Corinti S","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.4049\/jimmunol.158.6.2919","article-title":"Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: Evidence for a soluble CD14\u2010dependent pathway.","volume":"158","author":"Verhasselt V","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270805"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.6.3087-3095.1999"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01438-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2249"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.577-583.2000"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.6.979"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01346-2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.4049\/jimmunol.161.10.5663","article-title":"Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP) \u20101\u03b1 and MIP\u20101\u03b2.","volume":"161","author":"Tedla N","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1997.0242"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<1803::AID-IMMU1803>3.0.CO;2-F"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.8.1547"},{"key":"e_1_2_7_38_1","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.4049\/jimmunol.163.7.3890","article-title":"Dendritic cell (DC)\u2010based anti\u2010infective strategies: DCs engineered to secrete IL\u201012 are a potent vaccine in a murine model of an intracellular infection.","volume":"163","author":"Ahuja SS","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.5.809"},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.4049\/jimmunol.161.2.868","article-title":"Human dendritic cell (DC) \u2010based anti\u2010infective therapy: Engineering DCs to secrete functional IFN\u2010\u03b3 and IL\u201012.","volume":"161","author":"Ahuja SS","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510330076038"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-893"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-888"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.4.1702-1707.1999"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00703.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5229"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.4049\/jimmunol.158.9.4229","article-title":"Bone marrow\u2010derived dendritic cells can process bacteria for MHC\u2010I and MHC\u2010II presentation to T cells.","volume":"158","author":"Svensson M","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01358.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9966-8_31"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270941"},{"key":"e_1_2_7_51_1","first-page":"187","article-title":"The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by Cd1b molecules.","volume":"6","author":"Prigozy TI","year":"1997","journal-title":"Immunology"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9966-8_28"},{"key":"e_1_2_7_53_1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1128\/iai.65.3.1077-1082.1997","article-title":"Involvement of mannose receptor in cytokine interleukin\u20101\u03b2 (Il\u20101\u03b2), Il\u20106, and granulocyte\u2010macrophage colony\u2010stimulating factor responses, but not in chemokine macrophage inflammatory protein\u20101\u03b2 (Mip\u20101\u03b2), Mip\u20102, and Kc responses, caused by attachment of Candida albicans to macrophages.","volume":"65","author":"Yamamoto Y","year":"1997","journal-title":"Infect. Immun."},{"key":"e_1_2_7_54_1","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.4049\/jimmunol.159.5.2462","article-title":"Chitin particle\u2010induced cell\u2010mediated immunity is inhibited by soluble mannan \u2013 Mannose receptor\u2010mediated phagocytosis initiates Il\u201012 Production.","volume":"159","author":"Shibata Y","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1995.1110"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1995.1109"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/375151a0"},{"key":"e_1_2_7_58_1","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.4049\/jimmunol.157.4.1406","article-title":"Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.","volume":"157","author":"Finkelman FD","year":"1996","journal-title":"J. Immunol."},{"key":"e_1_2_7_59_1","first-page":"164","article-title":"Modulation of antigen processing and presentation by covalently linked complement C3b fragment.","volume":"84","author":"Jacquiersarlin MR","year":"1995","journal-title":"Immunology"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2494(96)87177-X"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5247.348"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)00045-X"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.732"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/32932"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.2.373"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.66.2.252"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01427-3"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/6995"},{"key":"e_1_2_7_69_1","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.4049\/jimmunol.161.9.4563","article-title":"CD40 Ligand\/Trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge.","volume":"161","author":"Gurunathan S","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00963.x"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1711.2000.00935.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1711.2000.00935.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.1440-1711.2000.00935.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1711.2000.00935.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T19:23:36Z","timestamp":1694028216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1711.2000.00935.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1046\/j.1440-1711.2000.00935.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1711.2000.00935.x","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}