{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:16:10Z","timestamp":1773288970439,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:bold>\n            <jats:italic>Background<\/jats:italic>\n          <\/jats:bold>: In various drug\u2010induced gastric mucosal injuries, it has been speculated that changes in gastric mucosal energy metabolism differ according to the cause of injury. This study was conducted to investigate the role of energy metabolism in two drug\u2010induced gastric mucosal injuries in humans.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods<\/jats:italic>\n          <\/jats:bold>: The subjects were patients with acute gastric mucosal injury due to non\u2010steroidal anti\u2010inflammatory drugs (NSAID) or steroids, and normal controls. Two sets of tissue specimens from the antrum and corpus of the stomach were obtained. One specimen from each area was used for histological analysis and the other was stored in liquid nitrogen. The stored tissues were homogenized. Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) were measured by the luciferin\u2013luciferase method.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Results and Conclusions<\/jats:italic>\n          <\/jats:bold>: In the NSAID group, the ATP levels and the total adenine nucleotide (TAN) levels in both the antrum and corpus were significantly lower than in the control group. In the steroid group, no significant differences were observed in either the ATP or TAN levels. The NSAID decreased energy metabolism in the entire stomach while the steroid had a negligible effect on energy metabolism.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2000.02063.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:13:46Z","timestamp":1047446026000},"page":"127-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of energy metabolism in drug\u2010induced acute gastric mucosal injuries in humans"],"prefix":"10.1111","volume":"15","author":[{"given":"Katsuyuki","family":"Sasahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)33103-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0016-5085(79)80183-3","article-title":"Measurement of hemoperfusion and oxygen sufficiency in gastric mucosa in vivo. Evidence of mucosal hypoxia as the cause of hemorrhagic shock\u2010induced gastric mucosal lesion in rats.","volume":"76","author":"Sato N","year":"1979","journal-title":"Gastroenterology"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0016-5085(74)80077-6","article-title":"Mechanism of stress ulcer. Influence of hypovolemic shock on energy metabolism in the gastric mucosa.","volume":"66","author":"Menguy R","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_6_5_2","first-page":"509","article-title":"Mechanism of stress ulcer II. Difference between the antrum, corpus and fundus with respect to the effects of complete ischemia on gastric mucosal energy metabolism.","volume":"66","author":"Menguy R","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/S0016-5085(74)80077-6","article-title":"Mechanism of stress ulcer. III. Effects of hemorrhagic shock on energy metabolism in the mucosa of the antrum, corpus and fundus of the rabbit stomach.","volume":"66","author":"Menguy R","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0016-5085(74)80077-6","article-title":"Mechanism of stress ulcer. IV. Influence of fasting on the tolerance of gastric mucosal energy metabolism to ischemia and on the incidence of stress ulceration.","volume":"66","author":"Menguy R","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01071959"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01072860"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0016-5085(82)80187-X","article-title":"Gastric mucosal hemodynamics after thermal or head injury. A clinical application of reflectance spectrophotometry.","volume":"83","author":"Kamada T","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529108998587"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(81)90144-5"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00851a033"},{"key":"e_1_2_6_14_2","first-page":"1","volume-title":"Working Party Reports of the World Congress of Gastroenterology","author":"Misiewicz JJ","year":"1990"},{"key":"e_1_2_6_15_2","first-page":"2074","article-title":"Gastric mucosal hemodynamics and aging. Clinical application of a non\u2010invasive, consecutive, high\u2010speed reflectance spectrophotometry.","volume":"78","author":"Sato N","year":"1981","journal-title":"Jpn. J. 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