{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:03:47Z","timestamp":1784545427717,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":603,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:bold>\n            <jats:italic>Background<\/jats:italic>\n          <\/jats:bold>: A questionnaire was used to record the clinical presentation of functional dyspepsia in relation to <jats:italic>Helicobacter pylori<\/jats:italic> infection in a consecutive series of patients sent for upper gastrointestinal endoscopy. Only patients without macroscopic abnormalities in their oesophagus, stomach and duodenum were included.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods<\/jats:italic>\n          <\/jats:bold>: The study questionnaire included two questions related to daily life, and the calculation of a symptom score. Biopsy specimens were taken from all patients for histological and microbiological examination, and immunoglobulin G antibodies were also determined.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Results<\/jats:italic>\n          <\/jats:bold>: Two hundred and twenty\u2010two patients were <jats:italic>H. pylori<\/jats:italic> positive and 182 patients were <jats:italic>H. pylori<\/jats:italic> negative. Loss of weight was significantly more common in the <jats:italic>H. pylori<\/jats:italic> positive group (<jats:italic>P<\/jats:italic> &lt; 0.001). Patients with <jats:italic>H. pylori<\/jats:italic> infection had a significantly higher overall symptom score compared with <jats:italic>H. pylori\u2010<\/jats:italic>negative subjects (<jats:italic>P<\/jats:italic> &lt; 0.05). In addition, the severity of epigastric and nocturnal pain, heartburn, retrosternal heartburn, and vomiting was significantly higher in <jats:italic>H. pylori<\/jats:italic>\u2010positive functional dyspeptic patients, and the influence on daily life and activities was significantly worse.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusions<\/jats:italic>\n          <\/jats:bold>: The combination of retrosternal pain, weight loss, food intolerance and the absence of halitosis signified a 64% accuracy in predicting <jats:italic>H. pylori<\/jats:italic> infection. It is not possible to differentiate between <jats:italic>H. pylori\u2010<\/jats:italic>positive and <jats:italic>H. pylori\u2010<\/jats:italic>negative functional dyspeptics on the basis of clinical presentation and the number of complaints. However, overall symptom score and severity of several symptoms was significantly higher in the <jats:italic>H. pylori<\/jats:italic>\u2010positive group.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2000.02080.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:14:37Z","timestamp":1047446077000},"page":"498-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical presentation of <i>Helicobacter pylori<\/i>\u2010positive and \u2010negative functional dyspepsia"],"prefix":"10.1111","volume":"15","author":[{"given":"Bibi Fm","family":"Werdmuller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toon Bmm Van Der","family":"Putten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton G","family":"Balk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius Bhw","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud Jlf","family":"Loffeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-12-199406150-00001"},{"key":"e_1_2_6_3_2","first-page":"1785","article-title":"Highly significant change of the clinical course of relapsing and complicated peptic ulcer disease after cure of Helicobacter pylori infection.","volume":"89","author":"Labenz J","year":"1994","journal-title":"Am. 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J. Gastroenterol."},{"key":"e_1_2_6_17_2","first-page":"11","article-title":"Comparison of symptoms between non\u2010ulcer dyspepsia positive and negative for C. pylori using a single bias computer system for history taking.","volume":"67","author":"Collins JS","year":"1989","journal-title":"Klin. Wochenschr."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087905"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02063953"},{"key":"e_1_2_6_20_2","first-page":"217","article-title":"Non\u2010ulcer dyspepsia: Is there any correlation between clinical symptoms and histopathological features?","volume":"23","author":"Petrolani S","year":"1991","journal-title":"Ital. J. 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