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Low dietary fat and genetically determined factors, such as body mass index and maximal acid output, may be important. Other dietary factors appear to be less relevant. Increased intake of carbonated drinks or aggravating medicines may influence the increasing rates of GORD in some Asian countries but no strong evidence links other factors, such as the age of the population, smoking or alcohol consumption, to GORD. The management of GORD in Asia is similar to that in Europe and North America but the lower incidence of severe oesophagitis in Asia may alter the approach slightly. Also, because Asians tend to develop stomach cancer at an earlier age, endoscopy is used routinely at an earlier stage of investigation. Gastro\u2010oesophageal reflux disease is essentially a motility disorder, so short\u2010term management of the disease can usually be achieved using prokinetic agents (or histamine (H<jats:sub>2<\/jats:sub>)\u2010receptor antagonists). More severe and recurrent GORD may require proton pump inhibitors (PPI) or a combination of prokinetic agents and PPI. The choice of long\u2010term treatment may be influenced by the relative costs of prokinetic agents and PPI.<\/jats:p><jats:p>\u00a9 2000 Blackwell Science Asia Pty Ltd<\/jats:p>","DOI":"10.1046\/j.1440-1746.2000.02148.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:14:01Z","timestamp":1047446041000},"page":"230-238","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Gastro\u2010oesophageal reflux disease in Asia"],"prefix":"10.1111","volume":"15","author":[{"given":"Khean\u2010Lee","family":"Goh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Sen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwong\u2010Ming","family":"Fock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyun","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo\u2010Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiu\u2010Kum","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"136","article-title":"Comparison of Olympus GIF\u2010P2 and GIF\u2010K panendoscopy.","volume":"78","author":"Chen PC","year":"1979","journal-title":"Taiwan I Hsueh Hui Tsa Chih"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018835324210"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.8.1020"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000200911"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199606000-00020"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1436"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529108996243"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528609034622"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296546"},{"key":"e_1_2_8_11_2","first-page":"350","article-title":"Adverse events of HP eradication: Long\u2010term negative consequences of HP eradication.","volume":"61","author":"Koster ED.","year":"1998","journal-title":"Acta Gastroenterol. 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