{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:19:02Z","timestamp":1777983542610,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":603,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:bold>\n            <jats:italic>Background<\/jats:italic>\n          <\/jats:bold>: Hepatic venous outflow obstruction (Budd\u2013Chiari syndrome) is frequently encountered as a cause of portal hypertension at our centre.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods and Results<\/jats:italic>\n          <\/jats:bold>: We studied the clinical presentation, therapeutic modalities and outcome of 71 patients with hepatic venous outflow obstruction between 1992 and 1997. Twenty\u2010seven patients presented with acute disease, while 44 had chronic presentation. Abdominal pain, distension, jaundice and upper gastrointestinal bleeding were the commonest presenting symptoms. The majority of patients had distended veins, hepatomegaly, splenomegaly, ascites and ankle oedema. The diagnosis was made on the basis of inferior vena cavography\/functional hepatography and pulsed Doppler ultrasonography and\/or liver biopsy in 39 patients and pulsed Doppler ultrasonography and\/or liver biopsy in 32 patients. Pulsed Doppler ultrasonography accurately detected the site of the block in 31 of 39 patients (79.4%). The obstruction was in the hepatic vein in 20 patients, in the inferior vena cava in 10, and in both in 41 patients. Aetiologically, four had pregnancy\u2010related disease, four tumour\u2010related, three hypercoagulable states, 18 inferior vena cava membranes and 42 were idiopathic. Of 30 patients in whom liver biopsy was carried out, eight had centrizonal congestion and necrosis, 13 had mixed features and nine had established cirrhosis. Seven patients underwent a shunt operation and surgical membranotomy was carried out in one. Three patients (4.2%) died in the hospital.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusions<\/jats:italic>\n          <\/jats:bold>: Hepatic venous outflow obstruction is a common problem; patients present with abdominal pain, distension, jaundice, distended veins, ascites and ankle oedema. Chronic presentation is more frequent. Pulsed Doppler ultrasound, venography and liver biopsy are very helpful in diagnosis.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2000.02157.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:14:37Z","timestamp":1047446077000},"page":"550-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Budd\u2013Chiari syndrome: Our experience of 71 patients"],"prefix":"10.1111","volume":"15","author":[{"given":"V","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sk","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ck","family":"Nain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bambery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yk","family":"Chawla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62109-0"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199401000-00003"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91712-U"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198207000-00001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-195912000-00002"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90855-3"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90180-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.13.5.372"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.qjmed.a030135"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.116.2.430"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01263104"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.163.2.3562813"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.146.6.1141"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb00873.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.161.2.8333368"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90785-J"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.170.3.2644659"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1985.01390300007001"},{"key":"e_1_2_5_20_2","first-page":"79","article-title":"Budd\u2013Chiari syndrome: clinical patterns and therapy.","volume":"51","author":"Powell\u2010Jackson PR","year":"1982","journal-title":"Q. J. Med."},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.1987.avs0050028"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0016-5085(75)80090-4","article-title":"The Budd\u2013Chiari syndrome: correlation between hepatic scintigraphy and the clinical, radiological and pathological findings in nineteen cases of hepatic venous outflow obstruction.","volume":"68","author":"Tavill AS","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_5_23_2","first-page":"33","article-title":"Long term results of treatment of Budd\u2013Chiari syndrome by side to side portacaval shunt.","volume":"168","author":"Orloff MJ","year":"1989","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.5.2138842"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80249-1"},{"key":"e_1_2_5_26_2","first-page":"511","article-title":"Hepatic transplantation with perioperative and long term anticoagulation as treatment for Budd\u2013Chiari syndrome.","volume":"166","author":"Campbell Jr DA","year":"1988","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820807"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90001-4"},{"key":"e_1_2_5_29_2","first-page":"151","article-title":"Hepatic venous outflow obstruction\u2014where East meets West.","volume":"17","author":"Editorial.","year":"1996","journal-title":"Trop. Gastroenterol."},{"key":"e_1_2_5_30_2","first-page":"91","article-title":"Obstructive disease of the inferior vena cava\u2014an idiopathic type of Budd\u2013Chiari syndrome.","volume":"18","author":"Okuda K.","year":"1997","journal-title":"Trop. Gastroenterol."},{"key":"e_1_2_5_31_2","first-page":"165","article-title":"Hepatic venous outflow obstruction in Nepal.","volume":"17","author":"Shrestha SM.","year":"1996","journal-title":"Trop. Gastroenterol."},{"key":"e_1_2_5_32_2","first-page":"53","article-title":"Hepatic venous outflow obstruction.","volume":"7","author":"Editorial.","year":"1994","journal-title":"Natl Med. J. India"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1746.2000.02157.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1746.2000.02157.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.1440-1746.2000.02157.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1746.2000.02157.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T03:51:15Z","timestamp":1694404275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1746.2000.02157.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1046\/j.1440-1746.2000.02157.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1746.2000.02157.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]},"assertion":[{"value":"2001-12-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}