{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:27:11Z","timestamp":1761236831620},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":572,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastro\u2010oesophageal reflux is a frequent, aspecific phenomenon in infants and children. The recommended approach in infants with uncomplicated regurgitation consists of reassurance of the parents and, if this fails, dietary recommendations in formula\u2010fed infants. If, despite these efforts, symptoms persist, administration of prokinetics, such as cisapride, is recommended prior to investigations such as oesophageal pH monitoring. Oesophageal pH monitoring is also recommended to document gastro\u2010oesophageal reflux disease in children with unusual presentations such as chronic respiratory disease. Today, cisapride is the drug of choice because it has the best efficacy and safety profile. In infants and children presenting with symptoms suggesting oesophagitis, endoscopy of the upper gastrointestinal tract is recommended. If there is severe oesophagitis, acid suppression with histamine H<jats:sub>2<\/jats:sub>\u2010receptor antagonists or proton pump inhibitors in combination with prokinetics, are recommended. In life\u2010threatening situations, or in patients that are resistant to or dependent on acid\u2010suppressive medication, a surgical procedure such as laparascopic Nissen procedure should be considered.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2000.02169.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:14:56Z","timestamp":1047446096000},"page":"593-603","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Diagnosis and treatment of gastro\u2010oesophageal reflux disease in infants and children"],"prefix":"10.1111","volume":"15","author":[{"given":"Yvan","family":"Vandenplas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badriul","family":"Hegar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1997.02170430035007"},{"key":"e_1_2_10_3_2","first-page":"55","volume-title":"Pediatric Gastrointestinal Motility Disorders.","author":"Orenstein S.","year":"1994"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01953980"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.1.51"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70341-0"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1998.10718767"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050613"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01481.x"},{"key":"e_1_2_10_10_2","first-page":"419","article-title":"A clinical trial with an anti\u2010regurgitation formula.","volume":"153","author":"Vandenplas Y","year":"1994","journal-title":"Eur. J. Pediatr."},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199505000-00104"},{"key":"e_1_2_10_12_2","first-page":"237","article-title":"Use of a new thickened formula for treatment of symptomatic gastro\u2010oesophageal reflux in infants.","volume":"29","author":"Borelli O","year":"1997","journal-title":"Ital. J. Gastroenterol. Hepatol."},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199810000-00011"},{"key":"e_1_2_10_14_2","first-page":"285","article-title":"Nutritional value of an \u2018anti\u2010regurgitation\u2019 formula.","volume":"61","author":"Levtchenko E","year":"1998","journal-title":"Acta Gastroenterol. Belg."},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(86)90177-2"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8223(94)90099-X"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb01278.x"},{"key":"e_1_2_10_18_2","first-page":"125","volume-title":"Disorders of Gastro\u2010Intestinal Motility in Childhood.","author":"Verlinden M","year":"1988"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(86)90002-3"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199801000-00016"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80592-4"},{"key":"e_1_2_10_22_2","first-page":"A29","article-title":"Clinical evaluation of gastroesophageal reflux in children: double\u2010blind study of cisapride vs metoclopramide.","volume":"85","author":"Mundo F","year":"1990","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.5.454"},{"issue":"1","key":"e_1_2_10_24_2","first-page":"40","article-title":"Domperidone drops in the symptomatic treatment of chronic paediatric vomiting and regurgitation. A comparison with metoclopramide.","volume":"55","author":"De Loore I","year":"1979","journal-title":"Postgrad. Med. J."},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199905000-00017"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199405000-00001"},{"key":"e_1_2_10_27_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1542\/peds.78.1.55","article-title":"Antacid and formula effects on gastric acidity in infants with gastroesophageal reflux.","volume":"78","author":"Sutphen JL","year":"1986","journal-title":"Pediatrics"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199811000-00014"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.17210"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091037"},{"key":"e_1_2_10_31_2","first-page":"7","article-title":"Physiopathological mechanisms of gastro\u2010oesophageal reflux: is motility the clue? Rev. Med.","volume":"15","author":"Vandenplas Y.","year":"1994","journal-title":"Brux."},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90630-6"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199210000-00011"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00445926"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80151-8"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80150-6"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80339-7"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(81)80698-7"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441604"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992288702600202"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1990.tb08547.x"},{"key":"e_1_2_10_42_2","first-page":"326","volume-title":"Gastrointestinal Dysmotility: Focus on Cisapride.","author":"Carrasco S","year":"1992"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209011187"},{"key":"e_1_2_10_44_2","first-page":"5","article-title":"Effectividad del cisapride en el trtamiento del reflujo gastroesofagico (RGE) in nonos. Valoracion de un estudio a doble ciego.","volume":"40","author":"Castro HE","year":"1994","journal-title":"An. Espegnol. Pediatr."},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.5.454"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.1.21"},{"key":"e_1_2_10_47_2","unstructured":"DaoudG GonzalezL MedinaMet al.Efficacy of cisapride in infants with apnea and gastroesophageal reflux evaluated by prolonged intraesophageal pH monitoring.Proceedings of the Second United European Gastroenterology Week Barcelona Spain 19\u201323 July 1993.1993;A107(Abstract)."},{"key":"e_1_2_10_48_2","unstructured":"DaoudG StanzioneC AbrahamAet al.Response to cisapride in children with respiratory symptoms and gastroesophageal reflux evaluated by prolonged intraesophageal pH monitoring.Proceedings of the Second United European Gastroenterology Week Barcelona Spain 19\u201323 July 1993.1993;A108(Abstract)."},{"key":"e_1_2_10_49_2","unstructured":"EvansDF LedinghamSJ KapilaL.The effect of medical therapy on gastro\u2010oesophageal reflux disease in children.Proceedings of the World Congresses of Gastroenterology Sydney Australia 26\u201331 August 1990.1990;A53(Abstract)."},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.5.618"},{"key":"e_1_2_10_51_2","first-page":"613","article-title":"Vulutazione dell\u2019 efficacia della cisapride nel trattamento del refluso gastro\u2010esofageo.","volume":"44","author":"Iacono G","year":"1992","journal-title":"Minerva Pediatr."},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950030403"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00173601"},{"key":"e_1_2_10_54_2","first-page":"325","volume-title":"Gastrointestinal Dysmotility: Focus on Cisapride.","author":"Rode H","year":"1992"},{"key":"e_1_2_10_55_2","first-page":"28","article-title":"Effect of cisapride on esophageal pH monitoring in children with reflux\u2010associated bronchopulmonary disease.","volume":"9","author":"Saye Z","year":"1989","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950030105"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198901000-00007"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199101000-00009"},{"key":"e_1_2_10_59_2","first-page":"669","article-title":"Effect of cisapride on excessive regurgitation in infants.","volume":"11","author":"Van Eygen M","year":"1989","journal-title":"Clin. Ther."},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199711000-00003"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70451-8"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1746.2000.02169.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1746.2000.02169.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.1440-1746.2000.02169.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1746.2000.02169.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:00:07Z","timestamp":1694415607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1746.2000.02169.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["10.1046\/j.1440-1746.2000.02169.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1746.2000.02169.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]},"assertion":[{"value":"2001-12-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}