{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:30:42Z","timestamp":1768415442497,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":511,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:bold>\n            <jats:italic>Background<\/jats:italic>\n          <\/jats:bold>: Irritable bowel syndrome (IBS) is a colonic function disorder. Both pinaverlum bromide (a selective calcium channel blocker) and mebeverine (an antispasmodic) are reported to be effective in the long\u2010term (12\u201316 weeks) treatment of IBS patients. Their efficacy in the short\u2010term treatment of IBS patients and colonic transit time is unclear. Furthermore, substance P and neuropeptide Y have either excitatory or inhibitory effects on colonic motility. Whether the efficacy of both drugs is mediated through these neuropeptides remains unknown.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods and Results<\/jats:italic>\n          <\/jats:bold>: A clinical trial was conducted with 91 patients with diarrhoea\u2010predominant IBS. After basal measurement of the total colonic transit time, IBS patients were randomized to receive either pinaverlum bromide (50 mg, t.i.d.) or mebeverine (100 mg, t.i.d.) for 2 weeks. The symptomatic scores regarding defaecation, total colonic transit time and serum levels of substance P and neuro\u2010peptide Y were measured before and after treatments. The daily defaecation frequency was markedly decreased after treatment (pinaverlum bromide, 2.9 \u00b1 1.2 <jats:italic>vs<\/jats:italic> 2.0 \u00b1 1.0, <jats:italic>P<\/jats:italic> &lt; 0.05; mebeverine, 2.7 \u00b1 1.1 <jats:italic>vs<\/jats:italic> 2.1 \u00b1 1.0, <jats:italic>P<\/jats:italic> &lt; 0.05). The stool consistency became well formed after both treatments (<jats:italic>P<\/jats:italic> &lt; 0.05). Both drugs similarly improved the global well\u2010being in these IBS patients (pinaverlum bromide <jats:italic>vs<\/jats:italic> mebeverine 73.4 <jats:italic>vs<\/jats:italic> 71.8%, <jats:italic>P<\/jats:italic> &gt; 0.05). The total colonic transit time was significantly prolonged only after pinaverlum bromide treatment (21.4 \u00b1 15.5 <jats:italic>vs<\/jats:italic> 30.8 \u00b1 14.8 h, <jats:italic>P<\/jats:italic> &lt; 0.01). Neither substance P nor neuropeptide Y serum level was significantly changed after either treatments.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusion<\/jats:italic>\n          <\/jats:bold>: Pinaverlum bromide and mebeverine have similar therapeutic efficacies on diarrhoeapredominant IBS patients. Prolonged colonic transit time may be one of the factors responsible for the efficacy of pinaverlum bromide on the IBS patients. Substance P and neuropeptide Y appear less important in the pathogenesis of diarrhoea\u2010predominant IBS.<\/jats:p><jats:p>\u00a9 2000 Blackwell Science Asia Pty Ltd<\/jats:p>","DOI":"10.1046\/j.1440-1746.2000.02230.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:15:35Z","timestamp":1047446135000},"page":"925-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Effect of a calcium channel blocker and antispasmodic in diarrhoea\u2010predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"15","author":[{"given":"Ching\u2010Liang","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Yen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Full\u2010Young","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen\u2010Shong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lih\u2010Jiun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei\u2010Hwa","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou\u2010Dong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/0016-5085(81)90085-8","article-title":"Irritable bowel\u2013still more questions than answers.","volume":"80","author":"Alpers DH.","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018848122993"},{"key":"e_1_2_5_4_2","first-page":"200","volume-title":"Evolving Concepts in Gastrointestinal Motility","author":"Thompson WG.","year":"1996"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90319-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0016-5085(81)90056-1","article-title":"Colonic motor and myoelectrical activity: A comparative study of normal subjects, psychoneurotic patients, and patients with irritable bowel syndrome.","volume":"80","author":"Latimer P","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60797-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1994.tb00322.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430180202"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90475-4"},{"key":"e_1_2_5_11_2","first-page":"232","article-title":"Mebeverine in patients with the irri\u2010table colon syndrome: double blind study.","volume":"77","author":"Tasman\u2010Jones C.","year":"1973","journal-title":"N. 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