{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:57:15Z","timestamp":1758121035179},"reference-count":36,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":460,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold> Endoscopic therapy is the first treatment modality in the management algorithm of upper gastrointestinal haemorrhage. In treating bleeding peptic ulcers, diluted epinephrine is first injected followed by targeted treatment to the vessel. Combination therapy adding thermocoagulation or thrombin\/fibrin products has been shown to further improve the rate of haemostasis. There is also some evidence to suggest that adjuvant use of optimal acid suppression using high\u2010dose proton pump inhibitors can reduce recurrent bleeding after initial endoscopic control. In treating acute variceal haemorrhage, early administration of vasoactive agents facilitates endoscopic treatment. These drugs should be continued during and after endoscopic therapy to prevent recurrent in\u2010hospital bleeding. Firm evidence exists to date that band ligation is the endoscopic treatment of choice in the acute control of bleeding varices and their secondary prophylaxis against recurrent bleeding. The role of band ligation as primary prophylaxis for first bleeding remains controversial. Transjugular intrahepatic porto\u2010systemic shunts are used as a rescue procedure when endoscopic treatment fails. In selected patients with recurrent variceal haemorrhage and good hepatic reserves, surgical shunts may be indicated.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2000.02258.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:17:00Z","timestamp":1047446220000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Management of upper gastrointestinal haemorrhage"],"prefix":"10.1111","volume":"15","author":[{"given":"James Yw","family":"Lau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_2","DOI":"10.1136\/bmj.311.6999.222"},{"key":"e_1_2_6_3_2","first-page":"A207","article-title":"Meta\u2010analysis of endoscopic injection therapy versus thermal methods in peptic ulcer hemorrhage.","volume":"110","author":"Naveau S","year":"1996","journal-title":"Gastroenterology"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_2","DOI":"10.1136\/gut.42.4.462"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_2","DOI":"10.1053\/gast.1996.v111.pm8780566"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_2","DOI":"10.1016\/s0140-6736(97)03233-9"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_2","DOI":"10.1136\/bmj.314.7090.1307"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_2","DOI":"10.1136\/gut.44.5.715"},{"doi-asserted-by":"crossref","unstructured":"SabatM VillanuevaJ&OrtizJet al.Final results of a prospective and randomized trial evaluating endoscopic hemoclip for bleeding peptic ulcer.Digestive Disease Week New Orleans 1998 May 1720;A3304.","key":"e_1_2_6_9_2","DOI":"10.1016\/S0016-5085(98)81108-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_2","DOI":"10.1056\/NEJM199704103361503"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_2","DOI":"10.3109\/00365529709007680"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_2","DOI":"10.3109\/00365529709007679"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_2","DOI":"10.1001\/archinte.158.1.54"},{"key":"e_1_2_6_14_2","first-page":"A232","article-title":"Intravenous omeprazole infusion after endoscopic ulcer hemostasis: A double\u2010blind placebo\u2010controlled randomized trial.","volume":"116","author":"Lau JY","year":"1999","journal-title":"Gastroenterology"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_2","DOI":"10.7326\/0003-4819-127-12-199712150-00002"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_2","DOI":"10.1056\/NEJM199903113401002"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_2","DOI":"10.1023\/A:1018816729449"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_2","DOI":"10.7326\/0003-4819-123-4-199508150-00007"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_2","DOI":"10.1053\/gast.1996.v110.pm8566601"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_2","DOI":"10.1002\/hep.510250113"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_2","DOI":"10.1002\/hep.510280215"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_2","DOI":"10.1055\/s-1999-22"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_2","DOI":"10.1053\/ge.1999.v50.98594"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_2","DOI":"10.1016\/S0140-6736(95)92708-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_2","DOI":"10.1056\/NEJM199508313330904"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_2","DOI":"10.1016\/S0140-6736(95)92840-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_27_2","DOI":"10.1016\/0016-5085(90)91166-4"},{"doi-asserted-by":"publisher","key":"e_1_2_6_28_2","DOI":"10.1016\/s0140-6736(97)05099-x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_29_2","DOI":"10.1016\/S0168-8278(97)80112-2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_30_2","DOI":"10.1002\/hep.510250608"},{"doi-asserted-by":"publisher","key":"e_1_2_6_31_2","DOI":"10.1056\/NEJM199904013401302"},{"doi-asserted-by":"publisher","key":"e_1_2_6_32_2","DOI":"10.1053\/gast.1996.v110.pm8608893"},{"doi-asserted-by":"publisher","key":"e_1_2_6_33_2","DOI":"10.1016\/s0140-6736(96)08189-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_34_2","DOI":"10.7326\/0003-4819-126-11-199706010-00002"},{"doi-asserted-by":"publisher","key":"e_1_2_6_35_2","DOI":"10.7326\/0003-4819-126-11-199706010-00001"},{"doi-asserted-by":"publisher","key":"e_1_2_6_36_2","DOI":"10.1053\/gast.1997.v113.pm9352865"},{"doi-asserted-by":"publisher","key":"e_1_2_6_37_2","DOI":"10.1097\/00000658-199609000-00014"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1746.2000.02258.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1746.2000.02258.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.1440-1746.2000.02258.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1746.2000.02258.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:19:26Z","timestamp":1694427566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1746.2000.02258.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":36,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1046\/j.1440-1746.2000.02258.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1746.2000.02258.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"type":"print","value":"0815-9319"},{"type":"electronic","value":"1440-1746"}],"subject":[],"published":{"date-parts":[[2000,10]]},"assertion":[{"value":"2002-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}