{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:11:54Z","timestamp":1761559914933},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":173,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold> We report here a patient with chronic active hepatitis who had no markers for hepatitis viruses and no hyper\u2010\u03b3\u2010globulinemia, but had high titers of antimitochondrial antibody. Serum levels of alkaline phosphatase were normal, and antinuclear antibody, antismooth muscle antibody, and antiliver kidney microsome antibody tested negative. The titers of antimitochondrial antibody exceeded 1:640, and the positivity for anti\u2010M2 was ascertained by using both ELISA and immunoblot with beef\u2010heart mitochondria and a recombinant pyruvate dehydrogenase E2 subunit as antigens. This patient responded to ursodeoxycholic acid (UDCA) therapy in the beginning, but her hepatitis flared up during UDCA therapy. In contrast, she responded completely to corticosteroid therapy. The clinical course and histological findings of this patient strongly suggest that this patient has autoimmune hepatitis.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2001.02413.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:20:13Z","timestamp":1047446413000},"page":"830-835","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of autoimmune hepatitis with a high titer of antimitochondrial antibody and normal <b>\u03b3<\/b>\u2010globulinemia"],"prefix":"10.1111","volume":"16","author":[{"given":"Minoru","family":"Shibata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Morizane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Onozuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Mitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604043341406"},{"key":"e_1_2_4_3_2","first-page":"1265","volume-title":"Sleisenger and Fordtran's, Gastrointestinal and Liver Disease: Pathophysiology\/Diagnosis\/Management","author":"Czaja AJ.","year":"1998"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296447"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160505"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432159"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90160-E"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90656-W"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80205-5"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/jcm.35.1.187-192.1997","article-title":"Comparison of plasma virus loads among individuals infected with hepatitis C virus (HCV) genotypes 1, 2, and 3 by quantiplex HCV RNA assay versions 1 and 2, Roche Monitor assay, and an in\u2013house limiting dilution method.","volume":"35","author":"Hawkins A","year":"1997","journal-title":"J. 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