{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:33:34Z","timestamp":1785342814619,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aims:<\/jats:bold> Interleukin\u201010 (IL\u201010) is a potent anti\u2010inflammatory and immunoregulatory cytokine. Mice deficient in IL\u201010 production (IL\u201010\u2212\/\u2212mice) develop a spontaneous chronic enterocolitis, suggesting that IL\u201010 is an important regulator of the mucosal immune response <jats:italic>in vivo<\/jats:italic>. The objective of this study was to determine the role of endogenous IL\u201010 in the host defense against gastric colonization by <jats:italic>Helicobacter pylori<\/jats:italic> by using IL\u201010\u2010deficient mice.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The IL\u201010\u2212\/\u2212mice were inoculated intragastrically with a mouse\u2010adapted <jats:italic>H. pylori<\/jats:italic> isolate (Sydney Strain 1). Gastric colonization by <jats:italic>H. pylori<\/jats:italic> (biopsy urease test and bacterial colony counts), serum levels of <jats:italic>H. pylori<\/jats:italic>\u2010specific immunoglobulin (Ig) M, A, G, isotypes of IgG, and the gastric mucosal inflammatory scores were determined 6 weeks after inoculation. Results were compared with those obtained from <jats:italic>H. pylori<\/jats:italic>\u2010infected control mice (IL\u201010 +\/\u2212mice).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The colonization of gastric mucosa by <jats:italic>H. pylori<\/jats:italic> was reduced approximately 100\u2010fold (<jats:italic>P<\/jats:italic>\u2264 0.0001) in IL\u201010\u2212\/\u2212mice (log<jats:sub>10<\/jats:sub> 4.87 \u00b1 0.26 CFU\/g tissue) as compared to IL\u201010+\/\u2212mice (log<jats:sub>10<\/jats:sub> 6.64 \u00b1 0.22 CFU\/g tissue). Furthermore, IL\u201010\u2212\/\u2212mice infected with <jats:italic>H. pylori<\/jats:italic> had significantly higher <jats:italic>H. pylori<\/jats:italic>\u2010specific IgA and IgG antibodies in serum (<jats:italic>P<\/jats:italic>\u2264 0.01), and developed much more severe chronic active gastritis than infected IL\u201010+\/\u2212mice. The median scores of the infiltration of gastric mucosa by mononuclear cells and neutrophils were up to threefold higher in IL\u201010\u2212\/\u2212mice than they were in IL\u201010+\/\u2212mice.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our studies suggest that endogenous IL\u201010 is an inhibitor of the protective immune response to <jats:italic>H. pylori<\/jats:italic> infection. Interleukin\u201010 participates in the downregulation of <jats:italic>H. pylori<\/jats:italic>\u2010induced gastric inflammatory responses, which apparently confers a survival advantage to the organism promoting more effective colonization of gastric mucosa.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2001.02459.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:19:25Z","timestamp":1047446365000},"page":"377-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Reduced colonization of gastric mucosa by <i>Helicobacter pylori<\/i> in mice deficient in interleukin\u201010<sup>1<\/sup>"],"prefix":"10.1111","volume":"16","author":[{"given":"Wangxue","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dairu","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinton S","family":"Chadwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80101-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609094526"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709025058"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.6.739"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.5.609"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1473"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.442"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.4049\/jimmunol.156.12.4729","article-title":"Helicobacter\u2010specific cell\u2010mediated immune responses display a predominant Th1 phenotype and promote a delayed\u2010type hypersensitivity response in the stomachs of mice.","volume":"156","author":"Mohammadi M","year":"1996","journal-title":"J. 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