{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:54:32Z","timestamp":1779144872653,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":203,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><\/jats:sec><jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>Low\u2010grade fasting hyperbilirubinemia is a common observation in healthy subjects (HS), whereas high\u2010grade fasting hyperbilirubinemia is believed to be a characteristic finding of Gilbert\u2019s syndrome. This study was undertaken to assess the role of mutation in bilirubin UDP\u2010 glycosyltransferase gene (<jats:italic>UGT1A1<\/jats:italic>) on fasting hyperbilirubinemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Analysis of <jats:italic>UGT1A1<\/jats:italic> and a caloric restriction test (400 kcal for 24 h) were performed in 56 healthy subjects (25 males, 31 females), and 28 patients with Gilbert\u2019s syndrome (18 males, 10 females). There were 29 healthy subjects with no mutation in <jats:italic>UGT1A1<\/jats:italic>, and 27 healthy subjects and 26 Gilbert\u2019s syndrome patients with mutations in the coding and\/or promoter (TATA box) regions of <jats:italic>UGT1A1<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The mean increment of serum bilirubin (\u0394SB) was 9.6 \u03bcmol\/L (males) and 4.1 \u03bcmol\/L (females) in subjects with no <jats:italic>UGT1A1<\/jats:italic> mutation. Subjects with mutation in <jats:italic>UGT1A1<\/jats:italic> showed higher levels of \u0394SB than individuals without mutation. Among healthy subjects, gender difference in \u0394SB values was observed only in individuals with the wild type of <jats:italic>UGT1A1<\/jats:italic>, but not in those with mutations in this gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The results of the present study suggest that <jats:italic>UGT1A1<\/jats:italic> mutation has a role in the development of high\u2010grade fasting hyperbilirubinemia after caloric restriction.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1440-1746.2001.02495.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:20:00Z","timestamp":1047446400000},"page":"678-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Role of <i>UGT1A1<\/i> mutation in fasting hyperbilirubinemia"],"prefix":"10.1111","volume":"16","author":[{"given":"Tomoaki","family":"Ishihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Kaito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban C","family":"Gabazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Ikoma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0950-3528(89)90004-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528109182033"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698202"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0928-4346(96)00313-1"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91266-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511023331802"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91273-8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8170"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2610"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010609"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90544-4"},{"key":"e_1_2_6_13_2","first-page":"156","volume-title":"Proceedings of the Fogarty International Symposium on the Chemistry and Physiology of Bile Pigments.","author":"Kutz K","year":"1977"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1746.2001.02495.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1746.2001.02495.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:43:32Z","timestamp":1697676212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1746.2001.02495.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1046\/j.1440-1746.2001.02495.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1746.2001.02495.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]},"assertion":[{"value":"2001-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}