{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:30:51Z","timestamp":1697430651651},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2002,1,11]],"date-time":"2002-01-11T00:00:00Z","timestamp":1010707200000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We experienced a female case with asymptomatic primary biliary cirrhosis that was associated with pernicious anemia after 16 years from the onset. She was 52 years old when she first visited a clinic in 1981 for liver dysfunction treatment. Antimitochondrial antibody was negative and antipyruvate dehydrogenase complex antibody was positive in a low titer in its immunoglobulin (Ig)M type. Histological examination of her liver revealed a presence of definite chronic non\u2010suppurative destructive cholangitis with numerous epithelioid cell granuloma. She had been given 600 mg of the oral daily dose of ursodeoxycholic acid since 1992. Macrocytic anemia incidiously appeared in September 1999. An immunological examination detected negative antiparietal cell antibodies and positive anti\u2010intrinsic factor antibodies. Her bone marrow smear showed numerous megaloblasts and serum vitamin B<jats:sub>12<\/jats:sub> in her blood was low at 99 pg\/mL. Severe reversed atrophic\u2010type gastritis (type A gastritis) was demonstrated by the use of dye\u2010endoscopy with Congo red. Her macrocytic anemia dramatically improved after intramuscular administration of vitamin B<jats:sub>12<\/jats:sub>. In conclusion, attention should be given to the association of pernicious anemia during the follow up of primary biliary cirrhosis.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2001.02572.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:18:25Z","timestamp":1047446305000},"page":"1420-1424","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A female with asymptomatic primary biliary cirrhosis associated with pernicious anemia"],"prefix":"10.1111","volume":"16","author":[{"given":"Toru","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terasu","family":"Honma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kisei","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Fuse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,11]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"239","volume-title":"Diseases of the Liver and Biliary Syste","author":"Sherlock S","year":"1997"},{"key":"e_1_2_5_3_2","unstructured":"Anaemia caused by vitamin B12deficiency. In:BeersMH BerkowR eds.The Merck Manual of Diagnosis and Therapy 17th edn.Whitehouse:Merck Co. Inc. 1999: Section 11\/Chapter127 (on\u2010line)http:\/\/www.merck.com\/pubs\/mmanual\/section11\/chapter127\/127c.htm."},{"key":"e_1_2_5_4_2","first-page":"109","article-title":"Cirrhose billiaire primitive et an\u00e8mie de biermer.","volume":"4","author":"Renoux M","year":"1980","journal-title":"Gastroenterol. Clin. Biol."},{"key":"e_1_2_5_5_2","first-page":"426","article-title":"Pernizi\u00f6se An\u00e4mie bei einer Patientin mit prim\u00e4rer billi\u00e4rer Zirrhose.","volume":"144","author":"Arikan E","year":"1994","journal-title":"Wien Med. Wschr."},{"key":"e_1_2_5_6_2","first-page":"545","article-title":"A case of primary biliary cirrhosis associated with pernicious anemia.","volume":"96","author":"Dohmen K","year":"1999","journal-title":"Nippon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113344"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0950-3528(87)90044-3"},{"key":"e_1_2_5_9_2","first-page":"816","article-title":"Parietalzellantik\u00f6rper bei prim\u00e4r bili\u00e4rer Zirrhose: pathogenetische oder diagnostische Bedeutung?","volume":"124","author":"Wirth HP","year":"1994","journal-title":"Schweiz Med. Wochenschr."},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.138.10.3525","article-title":"Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.","volume":"138","author":"Gershwin ME","year":"1987","journal-title":"J. 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