{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:54:24Z","timestamp":1792749264412,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p><jats:bold>Abstract\u2003<\/jats:bold> We describe an early gastric cardiac cancer in a patient who had suffered long\u2010term gastroesophageal reflux disease (GERD) but showed no evidence of infection with <jats:italic>Helicobacter pylori<\/jats:italic>. Proximal gastrectomy and partial resection of the lower esophagus was performed. Histological examination revealed the lesion to be a gastric cardiac adenocarcinoma, which had partially invaded the submucosal layer. Intestinal metaplasia was also found in some areas. Inflammation, however, appeared to be limited to the gastric cardia. This cancer may have arisen via a sequence of carditis and cardiac intestinal metaplasia, due primarily to the GERD and not to <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><jats:p>\u00a9 2002 Blackwell Publishing Asia Pty Ltd<\/jats:p>","DOI":"10.1046\/j.1440-1746.2002.02749.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:21:26Z","timestamp":1047446486000},"page":"1236-1238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An early cancer of the gastric cardia arising from carditis after long\u2010term gastroesophageal reflux disease in the absence of <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1111","volume":"17","author":[{"given":"Kazuyoshi","family":"Yagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Oyamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Tamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedenobu","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460100089030"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750024100"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.23.1734"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1997.tb00460.x"},{"key":"e_1_2_4_7_2","first-page":"37","article-title":"Pathology of the gastric cardia","volume":"83","author":"Rotterdam H","year":"1999","journal-title":"Verh. 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