{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:26:22Z","timestamp":1792740382234,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2002,8,30]],"date-time":"2002-08-30T00:00:00Z","timestamp":1030665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> As an important mechanism underlying the increased risk of colorectal carcinoma development in patients with long\u2010standing ulcerative colitis, promotion as a result of the regenerative process has been proposed. In the present study, a dysplasia\u2010carcinoma sequence in a novel repeated colitis model in mice is documented.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Repeated colitis was induced by nine administration cycles of 3% dextran sulfate sodium (DSS; molecular weight, 54\u2003000): each administration cycle comprised 3% DSS for 7\u2003days followed by distilled water for the subsequent 14\u2003days, to give conditions similar to the clinically observed active and remission phases in humans.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Multiple colorectal tumors (nine low\u2010 and four high\u2010grade dysplasias and two carcinomas) developed in 25 mice. These neoplastic lesions consisted of tubular structures, presenting as various types of elevated, flat and depressed tumor, similar to those in ulcerative colitis patients. A time\u2010course study with assessment of the severity of colitis and <jats:italic>in vivo<\/jats:italic> bromodeoxyuridine uptake during a single 3% DSS administration cycle revealed a high level of regenerative activity in the colitis\u2010affected mucosal epithelia.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Thus, with the present repeated colitis model, regeneration and neoplastic lesions were apparent, the biological features of which provide evidence of a colorectal dysplasia\u2013invasive carcinoma sequence in ulcerative colitis.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2002.02853.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:21:12Z","timestamp":1047446472000},"page":"1078-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Dysplasia and carcinoma development in a repeated dextran sulfate sodium\u2010induced colitis model"],"prefix":"10.1111","volume":"17","author":[{"given":"Isao","family":"Okayasu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetuo","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Ohkusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.7.5.427"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.35.020184.000341"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.7.800"},{"key":"e_1_2_6_5_2","first-page":"171","article-title":"Development of colorectal cancer in ulcerative colitis. 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