{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:37:36Z","timestamp":1793147856941,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,5,9]],"date-time":"2003-05-09T00:00:00Z","timestamp":1052438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> Eradication of <jats:italic>Helicobacter pylori<\/jats:italic> is not routinely recommended for the symptomatic relief and the prevention of gastric cancer in patients with functional dyspepsia. The present study investigated a useful indicator of <jats:italic>H.\u2003pylori<\/jats:italic> eradication in such patients by determining the optimal cutoff value of a <jats:sup>13<\/jats:sup>C\u2010urea breath test (UBT).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> One hundred dyspeptic patients participated in the study. Dyspepsia was scored, and a <jats:sup>13<\/jats:sup>C\u2010UBT administered. A level of delta <jats:sup>13<\/jats:sup>C\u2010UBT\u2003of&gt;4\u2030 was diagnosed as <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive. After the stomach was endoscopically sprayed with phenol red, biopsy specimens were taken from the antrum, body and cardia of the stomach for the assessment of <jats:italic>H.\u2003pylori<\/jats:italic> density, and activity (neutrophil infiltration) and degree (lymphocyte infiltration) of gastritis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Correlation between delta <jats:sup>13<\/jats:sup>C\u2010UBT and dyspepsia score was not found. Delta <jats:sup>13<\/jats:sup>C\u2010UBT significantly correlated with <jats:italic>H.\u2003pylori<\/jats:italic> density score in the total stomach (<jats:italic>r<\/jats:italic>\u2003=\u20030.53, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), neutrophil (<jats:italic>r<\/jats:italic>\u2003=\u20030.34, <jats:italic>P<\/jats:italic>\u2003=\u20030.0005) and lymphocyte score (<jats:italic>r<\/jats:italic>\u2003=\u20030.69, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Twenty\u2010six of the 100 subjects had a neutrophil score of \u22654, lymphocyte score of \u22654, and <jats:italic>H.\u2003pylori<\/jats:italic> score of \u22654. Their 95% confidence interval of mean was 58.2\u2030, which reflects moderate to marked acute and chronic gastritis, and dense <jats:italic>H.\u2003pylori<\/jats:italic> colonization.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The <jats:sup>13<\/jats:sup>C\u2010UBT is a reliable semiquantitative test to assess <jats:italic>H.\u2003pylori<\/jats:italic> density and the activity and degree of gastritis. It is proposed that <jats:italic>H.\u2003pylori<\/jats:italic> eradication therapy might be beneficial for patients with functional dyspepsia with a delta <jats:sup>13<\/jats:sup>C\u2010UBT of &gt;58.2\u2030.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2003.03049.x","type":"journal-article","created":{"date-parts":[[2003,5,9]],"date-time":"2003-05-09T10:43:02Z","timestamp":1052476982000},"page":"726-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Delta <sup>13<\/sup>C\u2010urea breath test value is a useful indicator for <i> Helicobacter pylori<\/i> eradication in patients with functional dyspepsia"],"prefix":"10.1111","volume":"18","author":[{"given":"YOUNG\u2010WOON","family":"CHANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUN\u2010KEE","family":"MIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KYUNG\u2010JIN","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YO\u2010SEOB","family":"HAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOO\u2010HEE","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEOK\u2010HO","family":"DONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HYO\u2010JONG","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BYUNG\u2010HO","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOUNG\u2010IL","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RIN","family":"CHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00770.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90606-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302043280503"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90113-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520010077036"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.1.8"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-1746.1998.tb00537.x","article-title":"Report of the 1997 Asia Pacific Consensus Conference of the management of H. pylori infection","volume":"13","author":"Lam SK","year":"1998","journal-title":"J. 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