{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:06:21Z","timestamp":1790175981439,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,7,14]],"date-time":"2003-07-14T00:00:00Z","timestamp":1058140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Balloon\u2010occluded retrograde transvenous obliteration (B\u2010RTO) is a novel therapeutic method for the treatment of large gastric fundal varices with spontaneous splenorenal shunt (SRS). However, the effects of B\u2010RTO on liver function remain unknown.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Fourteen patients with portal hypertension and gastric varices with SRS were studied, consisting of four patients with acute bleeding, five with high\u2010risk varices, and five with refractory portosystemic encephalopathy. Hepatic venous catheterization was performed to evaluate hepatic blood flow and liver function using the continuous indocyanine green (ICG) infusion method. To assess the metabolic activity of the hepatocyte, the intrinsic clearance of ICG was calculated. In all patients, endoscopic study was performed before and 1\u2003week and 1\u2003month after the B\u2010RTO, and followed every 6\u2003months thereafter. After baseline measurements, B\u2010RTO was performed. Four weeks after the B\u2010RTO, the same catheter measurements were repeated.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The B\u2010RTO was successful in all patients. Contrast\u2010enhanced computed tomography showed complete obliteration of the SRS prior to the follow\u2010up measurements. Endoscopic eradication of the fundal varices was obtained 6\u2003months after B\u2010RTO in all patients and encephalopathy was improved within 1\u2003week after B\u2010RTO. Following the B\u2010RTO, hepatic blood flow (441\u2003\u00b1\u2003214 <jats:italic>vs<\/jats:italic> 668\u2003\u00b1\u2003299\u2003mL\/min, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) and the intrinsic clearance of ICG (233\u2003\u00b1\u2003123 <jats:italic>vs<\/jats:italic> 285\u2003\u00b1\u2003148\u2003mL\/min, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) were significantly increased. Furthermore, intrahepatic resistance decreased after the B\u2010RTO (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> From short\u2010term assessment, B\u2010RTO increases hepatic blood flow and improves the metabolic activity of the liver in patients with portal hypertension.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2003.03087.x","type":"journal-article","created":{"date-parts":[[2003,7,14]],"date-time":"2003-07-14T13:35:37Z","timestamp":1058189737000},"page":"934-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Balloon\u2010occluded retrograde transvenous obliteration improves liver function in patients with cirrhosis and portal hypertension"],"prefix":"10.1111","volume":"18","author":[{"given":"YASUNAO","family":"MIYAMOTO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAZUHIKO","family":"OHO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAFUMI","family":"KUMAMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ATSUSHI","family":"TOYONAGA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHIO","family":"SATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,14]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1459","article-title":"A successfully treated case of fundic varices by retrograde transvenous obliteration with balloon","volume":"88","author":"Kanagawa H","year":"1991","journal-title":"Jpn. 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