{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:01:35Z","timestamp":1763114495034},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,8,11]],"date-time":"2003-08-11T00:00:00Z","timestamp":1060560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Little is known about the clinical efficacy of cotherapy of ecabet sodium, a mucoprotective agent, and a histamine H<jats:sub>2<\/jats:sub>\u2010receptor antagonist. The aim of the present study was to assess its additive benefit in combination with cimetidine for gastric ulcer.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In this prospective randomized study, after gastric ulcer was confirmed by endoscopy, 200 patients in 47 hospitals received either ecabet sodium 1\u2003g b.i.d and cimetidine 400\u2003mg b.i.d. (EC), or cimetidine 400\u2003mg b.i.d. alone (C) for 8 weeks. Healing was examined by endoscopy at 4 and 8 weeks.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the intention\u2010to\u2010treat (ITT) population (EC, 103; C, 97), 181 patients comprised the per protocol (PP) analysis (EC, 93; C, 88). At 4 weeks, healing rates were significantly higher in the EC group (60%) than in the C group (36%) ( <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01). At 8 weeks, those by the ITT and PP analyses were 82% (EC) <jats:italic>versus<\/jats:italic> 58% (C), and 90% (EC) <jats:italic>versus<\/jats:italic> 64% (C), respectively ( <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01 and <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.001). Symptom relief rates (EC <jats:italic>vs<\/jats:italic> C) at 2, 4 and 8 weeks were 73%<jats:italic>versus<\/jats:italic> 47% (<jats:italic> p<\/jats:italic>\u2003&lt;\u20030.01), 89%<jats:italic>versus<\/jats:italic> 66% ( <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.001), and 97%<jats:italic>versus<\/jats:italic> 73% (<jats:italic> p<\/jats:italic>\u2003&lt;\u20030.001), respectively. Significant additive effects of ecabet sodium were observed in patients aged 60 years or older, with solitary and medium to large ulcer, and without smoking or drinking habits. No adverse effects were critical.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Ecabet sodium significantly augmented gastric ulcer healing and symptom relief by cimetidine, especially in the elderly.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2003.03093.x","type":"journal-article","created":{"date-parts":[[2003,8,11]],"date-time":"2003-08-11T09:06:15Z","timestamp":1060592775000},"page":"1029-1033","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Combination therapy of ecabet sodium and cimetidine compared with cimetidine alone for gastric ulcer: Prospective randomized multicenter study"],"prefix":"10.1111","volume":"18","author":[{"given":"HIROAKI","family":"MURATA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUNAO","family":"KAWANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHINGO","family":"TSUJI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKENOBU","family":"KAMADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUUJI","family":"MATSUZAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KENICHI","family":"KATSU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KYOUICHI","family":"INOUE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KENICHI","family":"KOBAYASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SYOUJI","family":"MITSUFUJI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TADAO","family":"BAMBA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIRONAKA","family":"KAWASAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GOROU","family":"KAJIYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EIJI","family":"UMEGAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASANORI","family":"INOUE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ICHIMONJI","family":"SAITO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"16","author":"Marshall BJ","year":"1984","journal-title":"Lancet"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104113241507"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906173402407"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509107756"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005787"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529009091918"},{"key":"e_1_2_6_8_2","first-page":"1594","article-title":"Characteristics of gastric mucus in elderly patients with gastric ulcers","volume":"48","author":"Kishimoto M","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_9_2","first-page":"494","article-title":"Roles of prostaglandins, nitric oxide and the capsaicin\u2010sensitive sensory nerves in gastroprotection produced by ecabet sodium","volume":"275","author":"Kinoshita M","year":"1995","journal-title":"J. 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