{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:42:35Z","timestamp":1784608955888,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2003,10,13]],"date-time":"2003-10-13T00:00:00Z","timestamp":1066003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> causes chronic gastritis, peptic ulcer, gastric cancer and mucosa\u2010associated lymphoid tissue (MALT) lymphoma. Different genotypes of <jats:italic>H. pylori<\/jats:italic> are confirmed from diverse geographical areas. Its association with clinical diseases remains controversial. The aim of the present study was to investigate the <jats:italic>H. pylori<\/jats:italic> vacuolating cytotoxin (<jats:italic>vacA<\/jats:italic>) alleles, cytotoxin\u2010associated gene (<jats:italic>cagA<\/jats:italic>) and <jats:italic>iceA<\/jats:italic>, in patients with peptic ulcer and gastritis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We enrolled patients with peptic ulcer and chronic gastritis. Biopsy specimens were obtained from the antrum and lower body of the stomach. DNA extraction and polymerase chain reaction (PCR) were used to detect the presence or absence of <jats:italic>cagA<\/jats:italic> and to assess the polymorphism of <jats:italic>vacA and iceA.<\/jats:italic><\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A total of 133 patients (57 gastric ulcer, 52 duodenal ulcer, 24 chronic gastritis) had positive PCR results from biopsy specimens. Concerning genotypes, we found <jats:italic>cagA<\/jats:italic> (79% in the antrum, 92% in the body) and <jats:italic>iceA1<\/jats:italic> (73% in the antrum, 82.8% in the body) strains in the majority of patients. The dominant <jats:italic>vacA<\/jats:italic> subtype was s1a (74.4% in the antrum, 75% in the body), followed by s1c (51.1% in the antrum, 60.5% in the body). In the middle region, the m2 strain dominated (49.6% in the antrum, 41.4% in the body), followed by m1T (19.5% in the antrum, 9.5% in the body). Mixed infection occurred in 89 patients (67%). There was no statistical difference in genotypes among the three groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In Taiwan, <jats:italic>H. pylori<\/jats:italic> with positive <jats:italic>cagA<\/jats:italic> and <jats:italic>iceA1<\/jats:italic> was found in the majority of cases. <jats:italic>H. pylori<\/jats:italic> with v<jats:italic>acA<\/jats:italic> s1a strains was the most common <jats:italic>vacA<\/jats:italic> subtype, followed by s1c, while s1b was rare. In the middle region, the m2 subtype was predominant followed by m1T. There was no significant association between genotypes and clinical diseases.<\/jats:p>","DOI":"10.1046\/j.1440-1746.2003.03214.x","type":"journal-article","created":{"date-parts":[[2003,10,16]],"date-time":"2003-10-16T05:29:23Z","timestamp":1066282163000},"page":"1244-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Helicobacter pylori cagA<\/i>, <i>iceA<\/i> and <i>vacA<\/i> status in Taiwanese patients with peptic ulcer and gastritis"],"prefix":"10.1111","volume":"18","author":[{"given":"CHIN\u2010LIN","family":"PERNG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HWAI\u2010JENG","family":"LIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"FACG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010CHEN","family":"SUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUAN\u2010YING","family":"TSENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119588"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.720"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.19.5137"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.3.739-741.1992"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.90.12.5791","article-title":"Molecular characterization of the 128\u2010kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer","volume":"90","author":"Covacci A","year":"1993","journal-title":"Proc. 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