{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:28:56Z","timestamp":1777400936432,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":510,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p> <jats:bold>Objectives<\/jats:bold>: To identify the types of early cranial ultrasound changes that were significant predictors of adverse outcome during the first year of life in asphyxiated term infants.<\/jats:p><jats:p> <jats:bold>Methodology<\/jats:bold>: This was a prospective cohort study. Shortly after birth, cranial ultrasonography was carried out via the anterior fontanelles of 70 normal control infants and 104 asphyxiated infants with a history of fetal distress and Apgar scores of less than 6 at 1 and 5 min of life, or requiring endotracheal intubation and manual intermittent positive pressure ventilation for at least 5 min after birth. Neurodevelopmental assessment was carried out on the survivors at 1 year of age.<\/jats:p><jats:p> <jats:bold>Results<\/jats:bold>: Abnormal cranial ultrasound changes were detected in a significantly higher proportion (79.8%, or <jats:italic>n<\/jats:italic> = 83) of asphyxiated infants than controls (39.5%, or <jats:italic>n<\/jats:italic> = 30) (<jats:italic>P<\/jats:italic> &lt; 0.0001). However, logistic regression analysis showed that only three factors were significantly associated with adverse outcome at 1 year of life among the asphyxiated infants. These were: (i) decreasing birthweight (for every additional gram of increase in birthweight, adjusted odds ratio (OR) = 0.999, 95% confidence interval (CI) 0.998, 1.000; <jats:italic>P<\/jats:italic> = 0.047); (ii) a history of receiving ventilatory support during the neonatal period (adjusted OR = 8.3; 95%CI 2.4, 28.9; <jats:italic>P<\/jats:italic> = 0.0009); and (iii) hypoxic\u2010ischaemic encephalopathy stage 2 or 3 (adjusted OR = 5.8; 95%CI 1.8, 18.6; <jats:italic>P<\/jats:italic> = 0.003). None of the early cranial ultrasound changes was a significant predictor.<\/jats:p><jats:p> <jats:bold>Conclusions<\/jats:bold>: Early cranial ultrasound findings, although common in asphyxiated infants, were not significant predictors of adverse outcome during the first year of life in asphyxiated term infants.<\/jats:p>","DOI":"10.1046\/j.1440-1754.2000.00518.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T08:14:07Z","timestamp":1047456847000},"page":"363-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Early cranial ultrasound changes as predictors of outcome during first year of life in term infants with perinatal asphyxia"],"prefix":"10.1111","volume":"36","author":[{"given":"Ny","family":"Boo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Zulfiqar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sm","family":"Zamratol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mk","family":"Nyein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ms","family":"Haliza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ms","family":"Lye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"142","article-title":"A 2\u2010year study of neonatal mortality in a large Malaysian Hospital.","volume":"32","author":"Boo NY","year":"1991","journal-title":"Sing. 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