{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T12:46:07Z","timestamp":1781354767266,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>An autopsy case of hypertrophic pachymeningitis and multiple cranial neuropathies is reported. A 53\u2010year\u2010old woman with paraplegia and various neurological signs which developed over a 2 year period was diagnosed as having an epidural mass with thickened dura mater extending from the lower cervical to the thoracic spinal cord. In addition, bilateral episcleritis, blephaloptosis, and blindness of the right eye with various cranial nerve deficits were found to be caused by the mass lesions involving the paranasal sinuses, orbit, and the cavernous sinus. Perinuclear antineutrophil cytoplasmic antibody (p\u2010ANCA) was positive, but cytoplasmic antineutrophil cytoplasmic antibody (c\u2010ANCA) was negative by enzyme\u2010linked immunosorbent assay. The partially removed epidural mass with hypertrophied dura mater and biopsy of the paranasal lesions showed chronic granulomatous inflammation with vasculitis. The remaining lesions resolved with steroid therapy with remarkable neurological improvement. The positive p\u2010ANCA test, paranasal involvement, the report of a similar histopathological case and a review of the literature on granulomatous pachymeningitis suggest the presence of p\u2010ANCA\u2010positive Wegener\u2019s granulomatosis with central nervous system involvement characterized by hypertrophic pachymeningitis and\/or multiple cranial neuropathies.<\/jats:p>","DOI":"10.1046\/j.1440-1789.2000.00282.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:05:49Z","timestamp":1047481549000},"page":"23-30","source":"Crossref","is-referenced-by-count":96,"title":["P\u2010ANCA\u2010positive Wegener\u2019s granulomatosis presenting with hypertrophic pachymeningitis and multiple cranial neuropathies: Case report and review of 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