{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:24:13Z","timestamp":1794489853256,"version":"4.9.1"},"reference-count":43,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":490,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>Minamata disease (methylmercury poisoning) was first discovered in 1956 around Minamata Bay, Kumamoto Prefecture, Japan. A second epidemic in Japan occurred in 1965 along the Agano River, Niigata Prefecture. This paper presents a brief review of Minamata disease with an emphasis on the cases found in Kumamoto Prefecture. At autopsy, the most conspicuous destructive lesion in the cerebrum was found in the anterior portions of the calcarine cortex. Less severe but similar lesions may be found in the post\u2010central, pre\u2010central and temporal transverse cortices. Secondary degeneration from primary lesions may be seen in cases with long survival. In the cerebellum, pathological changes occur deep in the hemisphere. The granule cell population was more affected, compared with Purkinje cells. Among peripheral nerves, sensory nerves were more affected than motor nerves. Our recent experimental studies that reveal knowledge of the pathogenesis of methylmercury poisoning will be discussed.<\/jats:p>","DOI":"10.1046\/j.1440-1789.2000.00295.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:06:53Z","timestamp":1047481613000},"page":"14-19","source":"Crossref","is-referenced-by-count":196,"title":["Minamata disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Komyo","family":"Eto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,4]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"1","volume-title":"Minamata Disease.","author":"Kumamoto University Study Group for Minimata Disease.","year":"1968"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/019262339702500612"},{"key":"e_1_2_8_4_2","first-page":"83","volume-title":"Handbook of Clinical Neurology","author":"Shiraki H.","year":"1979"},{"key":"e_1_2_8_5_2","first-page":"1651","volume-title":"Pathology of Nervous System (II).","author":"Shiraki H","year":"1971"},{"key":"e_1_2_8_6_2","first-page":"247","volume-title":"Environmental Mercury Contamin\u2010ation.","author":"Takeuchi T.","year":"1972"},{"key":"e_1_2_8_7_2","first-page":"235","volume-title":"Neurotoxicology","author":"Takeuchi T.","year":"1977"},{"key":"e_1_2_8_8_2","first-page":"27","volume-title":"Minamata Disease.","author":"Takeuchi T.","year":"1979"},{"key":"e_1_2_8_9_2","first-page":"345","volume-title":"Neurotoxicology.","author":"Takeuchi T.","year":"1985"},{"key":"e_1_2_8_10_2","first-page":"28","volume-title":"Studies on the Health Effects of Alkylmercury in Japan.","author":"Takeuchi T","year":"1975"},{"key":"e_1_2_8_11_2","first-page":"103","volume-title":"Minamata Disease: Methylmercury Poisoning in Minamata and Niigata, Japan.","author":"Takeuchi T","year":"1977"},{"key":"e_1_2_8_12_2","first-page":"117","volume-title":"Recent Advances in Minamata Disease Studies: Methylmercury Poisoning in Minamata and Niigata, Japan.","author":"Takeuchi T","year":"1986"},{"key":"e_1_2_8_13_2","first-page":"1","article-title":"Neuropathology of childhood cases of methylmercury poisoning (Minamata disease) with prolonged symptoms, with particular reference to the decortication syndrome.","volume":"1","author":"Takeuchi T","year":"1979","journal-title":"Neurotoxicol"},{"key":"e_1_2_8_14_2","first-page":"60","article-title":"The resolution of the cause in an occurrence in Minamata disease (1) (in Japanese).","volume":"323","author":"Nishimura K.","year":"1998","journal-title":"Gendai Kagaku [Chem Today]"},{"key":"e_1_2_8_15_2","first-page":"132","article-title":"Outbreak of intoxication by organic compounds in Niigata Prefecture.","volume":"6","author":"Tsubaki T.","year":"1967","journal-title":"Jpn J Med"},{"key":"e_1_2_8_16_2","first-page":"145","article-title":"A pathological study on the fetal Minamata disease diagnosed clinically so\u2010called infantile cerebral palsy (in Japanese).","volume":"8","author":"Takeuchi T","year":"1964","journal-title":"Adv Neurol Sci"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196510000-00002"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.17.4.235"},{"key":"e_1_2_8_19_2","first-page":"2007","volume-title":"Spez Path Ant U Histol XIII\/2, B.","author":"Pentschew A.","year":"1958"},{"key":"e_1_2_8_20_2","unstructured":"TakeuchiT Second Study Group for Minamata Disease.Pathological clinical and epidemiological research about Minamata disease after ten years (in Japanese).Kumamoto:Kumamoto University 1973."},{"key":"e_1_2_8_21_2","volume-title":"The Pathology of Minamata Disease. 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