{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:12:33Z","timestamp":1791238353831,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":490,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>HTLV\u2010I was first described as a pathogenic human retrovirus that causes adult T\u2010cell leukemia (ATL). Soon after the discovery of HTLV\u2010I, an association of this virus with a slowly progressive neurological disorder was found independently in Japan and Caribbean islands, and this new clinical entity (HTLV\u2010I\u2010associated myelopathy with tropical spastic paraparesis) was named HAM\/TSP. Autopsy findings clarified the chronic inflammatory nature of the disease. Detailed neuropathological analysis demonstrated: (i) T\u2010cell\u2010dominant mononuclear cell infiltration; (ii) diffuse and symmetrical degeneration of the antero\u2010lateral and inner portion of the posterior columns involving both myelin and axons; (iii) the presence of cytotoxic T cells and apoptosis of helper\/inducer T cells; (iv) <jats:italic>in vivo<\/jats:italic> localization of HTLV\u2010I provirus in the perivascular infiltrated T cells; and (v) accentuation of inflammatory lesions at the site with slow blood flow. From these findings it is suggested that a T\u2010cell\u2010mediated chronic inflammatory process targeting the HTLV\u2010I\u2010infected T cells is the primary pathogenic mechanism of HAM\/TSP.<\/jats:p>","DOI":"10.1046\/j.1440-1789.2000.00320.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:06:53Z","timestamp":1047481613000},"page":"65-68","source":"Crossref","is-referenced-by-count":49,"title":["HTLV\u2010I\u2010associated myelopathy"],"prefix":"10.1111","volume":"20","author":[{"given":"Shuji","family":"Izumo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujio","family":"Umehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Osame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,4]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"73","volume-title":"Topics in Hematology.","author":"Takatsuki K","year":"1977"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3618"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91984-2"},{"key":"e_1_2_9_9_2","first-page":"261","volume-title":"HTLV\u2010I and the Nervous System.","author":"Izumo S","year":"1989"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(90)90060-Z"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199307000-00010"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199401000-00009"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050435"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199411000-00009"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)90060-4"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050903"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400114"},{"key":"e_1_2_9_18_2","unstructured":"Moe MoeAye MatsuokaE MoritoyoTet al.Histopathologic analysis of four autopsy cases of HAM\/TSP. Inflammatory changes occur simultaneously in the entire CNS.Acta Neuropathol2000; in press."},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199809000-00005"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-5728(99)00155-1"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1789.2000.00320.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1789.2000.00320.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T04:56:17Z","timestamp":1695704177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1789.2000.00320.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":19,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["10.1046\/j.1440-1789.2000.00320.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1789.2000.00320.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}