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A four\u2010syndrome classification was proposed in which \u2018alienation syndrome\u2019 is separated from delusion syndrome. Memory organization deficit in schizophrenia patients was correlated with reduced activation of the left inferior frontal regions. Magnetic resonance imaging and statistical parametric mapping analysis revealed that volume reduction in the temporal lobe was seen in both schizotypal disorder and schizophrenia patients, but schizophrenia patients had additional changes in the medial and dorsolateral frontal regions. In conclusion, a temporo\u2010frontal dual pathology of schizophrenia was suggested.<\/jats:p>","DOI":"10.1046\/j.1440-1819.2003.01072.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T16:34:57Z","timestamp":1047486897000},"page":"3-8","source":"Crossref","is-referenced-by-count":27,"title":["Pathogenesis of schizophrenia: Part I. 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