{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:30:12Z","timestamp":1764401412419},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>It is very important to develop and analyze animal models of Epstein\u2013Barr virus (EBV)\u2010associated tumors in the human. However, only a few reports on the animal models of EBV infection have been reported. Here we review those previous models and describe the details on our newly developed rabbit model of malignant lymphoma induced by EBV\u2010related virus from cynomolgus. In brief, Si\u2010IIA\u2010EBV or Cyno\u2010EBV induced T\u2010cell lymphomas in rabbits inoculated intravenously (77\u201390%), orally (82\u201389%), subcutaneously (3\/3) and intraperitoneally (2\/3) about 2\u20135 months later. EBV\u2010DNA was detected in peripheral blood by polymerase chain reaction 2 days after oral inoculation of Cyno\u2010EBV while antiviral capsid antigen immunoglobulin G (IgG) was raised 3 weeks after the inoculation. Rabbit lymphomas and their cell lines contained EBV\u2010DNA and expressed EBV\u2010encoded small RNA\u20101 and EBV\u2010associated nuclear antigen. Rabbit lymphoma cell lines, some of which have specific chromosomal abnormality, showed tumorigenicity in nude mice. The significance and further research subjects of this animal model will be discussed. We believe that the present rabbit model of lymphoma with specific chromosomal abnormalities is very useful for clarifying the role of EBV in human EBV\u2010associated lymphoma and provides a means for studying prophylactic and therapeutic regimens.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01018.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:14:32Z","timestamp":1047489272000},"page":"85-97","source":"Crossref","is-referenced-by-count":15,"title":["An animal model for Epstein\u2013Barr virus (EBV)\u2010associated lymphomagenesis in the human: Malignant lymphoma induction of rabbits by EBV\u2010related herpesvirus from cynomolgus"],"prefix":"10.1111","volume":"50","author":[{"given":"Kazuhiko","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaatsu","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_2_10_3_2","first-page":"2397","volume-title":"Fields Virology","author":"Rickinson AB","year":"1996"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902233200806"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-199601000-00001"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1996.tb01414.x"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199203000-00037"},{"key":"e_1_2_10_8_2","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.1128\/jvi.67.10.6303-6308.1993","article-title":"Epstein\u2010Barr virus (EBV) gene expression in EBV\u2010positive peripheral T\u2010cell lymphomas.","volume":"67","author":"Chen CL","year":"1993","journal-title":"J. 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