{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:20:11Z","timestamp":1759742411149},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>TCL1<\/jats:italic> gene, localized near the break point of chromosome 14q32.1 often involved in T cell leukemias, is also expressed in normal precursor T and B cells, and B cell lymphoma cell lines. We investigated the expression of the TCL1 protein in various types of B cell lymphomas according to the Revised European\u2013American Classification of Lymphoid neoplasms. Paraffin\u2010embedded tissue sections of lymphoma specimens were subjected to TCL1 immunohistochemistry, and positivity was scored on a three\u2010tiered scale: \u2013 (<jats:bold>&lt;<\/jats:bold> 25% cells), <jats:bold>+<\/jats:bold> (25\u201350% cells), and <jats:bold>++<\/jats:bold> (<jats:bold>&gt;<\/jats:bold> 50% cells). The TCL1 protein was expressed in low\u2010grade B cell lymphomas including mucosa\u2010associated lymphoid tissue type in ocular adnexa (18\/20, 90%). It was also expressed in follicular, lymphoplasmacytic, and mantle cell lymphoma, but not in high\u2010grade diffuse large B cell lymphoma (2\/11, 18%). These data suggest that the expression of the <jats:italic>TCL1<\/jats:italic> gene characterizes low\u2010grade B cell lymphomas, and may be involved in certain processes of lymphomatogenesis.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01023.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:14:37Z","timestamp":1047489277000},"page":"191-199","source":"Crossref","is-referenced-by-count":23,"title":["Activation of the TCL1 protein in B cell lymphomas"],"prefix":"10.1111","volume":"50","author":[{"given":"Ichiro","family":"Nakayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Murao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohei","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Azumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misao","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakan","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"9275","article-title":"Molecular analysis of a t(14;14) translocation in leukemic T\u2010cells of an ataxia teleangiectasia patient. Proc. Natl Acad.","volume":"90","author":"Russo G","year":"1993","journal-title":"Sci. USA"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12530"},{"key":"e_1_2_6_4_2","first-page":"6297","article-title":"Characterization and localization of the TCL1 oncogene product.","volume":"54","author":"Fu T\u2010B","year":"1994","journal-title":"Cancer Res."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3885"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1182\/blood.V87.5.1923.1923","article-title":"Expression of p13 MTCP1 is restricted to mature T cell proliferations with t (X:14) translocation.","volume":"87","author":"Madani A","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_7_2","first-page":"2475","article-title":"MTCP1: A novel gene on the human chromosome Xq28 translocated to the T cell receptor \u03b1\/\u03b4 locus in mature T cell proliferations.","volume":"8","author":"Stern MH","year":"1993","journal-title":"Oncogene"},{"key":"e_1_2_6_8_2","first-page":"379","article-title":"Expression of either TCL1 oncogene, or transcripts from its homologue MTPC1\/c6.1B, in leukemic and non\u2010leukemic T cells from ataxia telangiectasia patients.","volume":"12","author":"Thick J","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1998.tb03275.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201246"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9809"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A Revised European\u2010American Classification of lymphoid Neoplasms: A proposal from the international lymphoma study group.","volume":"85","author":"Harris NL","year":"1994","journal-title":"Blood"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/7.suppl_6.S3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1998.tb03914.x"},{"key":"e_1_2_6_16_2","first-page":"181","article-title":"Conjuctival\u2010associated lymphoid tissue. Evidence for a role in the secretory immune system. Invest.","volume":"25","author":"Franklin RM","year":"1984","journal-title":"Ophthalmol. Visual Sci."},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30764-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)98024-1"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00196816"},{"key":"e_1_2_6_20_2","first-page":"263","volume-title":"Tumors of the eye and ocular adnexa. 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