{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:11:51Z","timestamp":1698642711842},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two polymeric autosomal loci, <jats:italic>Ten1<\/jats:italic> and <jats:italic>Ten2<\/jats:italic>, regulate thymus enlargement in BUF\/Mna (B) rats. Previously, we mapped <jats:italic>Ten1<\/jats:italic> on chromosome (Chr) 1 to a 20 cM region between <jats:italic>Myl2<\/jats:italic> and <jats:italic>D1Mgh11<\/jats:italic>, and <jats:italic>Ten2<\/jats:italic> on Chr 13. To further characterize the precise position of <jats:italic>Ten1<\/jats:italic>, 34 and 37 microsatellite markers, that have a polymorphism between the B and WYK (W) and between the B and MITE (M) strains, were used for linkage analysis of thymus enlargement in 105 (WBF1 <jats:bold>\u00d7<\/jats:bold> B) blackcross (BC) and 78 (B <jats:bold>\u00d7<\/jats:bold> BMF1) BC rats, respectively. Our data showed that the <jats:italic>D1Rat168<\/jats:italic>, <jats:italic>D1Rat112<\/jats:italic>, <jats:italic>D1Rat323<\/jats:italic>, <jats:italic>D1Got186<\/jats:italic>, <jats:italic>D1Got187<\/jats:italic> and <jats:italic>D1Got188<\/jats:italic> markers each gave a peak logarithm of odds (LOD) score of 10.68 for linkage to the thymus ratio in (WBF1 <jats:bold>\u00d7<\/jats:bold> B) BC rats, and that the <jats:italic>D1Rat168<\/jats:italic>, <jats:italic>D1Rat197<\/jats:italic>, <jats:italic>D1Got184<\/jats:italic>, <jats:italic>D1Got186<\/jats:italic> and <jats:italic>D1Got188<\/jats:italic> markers each gave a peak LOD score of 7.82 in (B <jats:bold>\u00d7<\/jats:bold> BMF1) BC rats. The two LOD score peaks are coincident in the position of the rat genetic map. All of the markers mentioned above are located in the region between <jats:italic>Igf2<\/jats:italic> and <jats:italic>D1Mgh11<\/jats:italic>, in which synteny is conserved with human 11q15.5 and the distal end of mouse Chr 7 or with human 11q13 and the proximal end of mouse Chr 19. Genes existing in these regions are discussed as candidate genes for <jats:italic>Ten1<\/jats:italic>.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01031.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:14:37Z","timestamp":1047489277000},"page":"185-190","source":"Crossref","is-referenced-by-count":0,"title":["Fine mapping of thymus enlargement gene 1 (<i>Ten1<\/i>) in BUF\/Mna rats"],"prefix":"10.1111","volume":"50","author":[{"given":"Chunlin","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Murakumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Higo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsushi","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-84110-1_43"},{"key":"e_1_2_6_3_2","first-page":"2771","article-title":"Ultrastructure of spontaneous and urethan\u2010induced thymomas in Buffalo rats.","volume":"35","author":"Matsuyama M","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_6_4_2","first-page":"209","article-title":"Strain difference in carcinogenesis by urethan administration to suckling rats.","volume":"63","author":"Matsuyama M","year":"1972","journal-title":"Gann"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.279"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(93)90099-D"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.182.309"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1993.tb02054.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900152"},{"key":"e_1_2_6_10_2","first-page":"436","article-title":"Genetic mapping of genes regulating the thymus size in back\u2010cross rats between the laboratory BUF\/Mna strain and the MITE strain derived from the wild rat, Rattus norvegicus. 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