{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:49:19Z","timestamp":1792363759567,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mercury contamination is a serious environmental problem worldwide. Two primary sources of contamination are dumping of large quantities of inorganic mercury and exposure in the mining industry. Although the actual fatal level of mercury vapor is not known, exposure to more than 1\u20132 mg\/m<jats:sup>3<\/jats:sup> of elemental mercury vapor (Hg<jats:sup>0<\/jats:sup>) for a few hours causes acute chemical bronchiolitis and pneumonitis. Two hours after exposure, lung injury appears as hyaline membrane formation, and finally, extensive pulmonary fibrosis occurs. Clinical findings correlate with the duration of exposure, the concentration of mercury, and the survival time after exposure. There is no correlation between pathological findings and the concentration of mercury in the tissues. Necrosis of proximal convoluted tubules may be attributed to the disruption of the enzyme systems of Hg<jats:sup>2<jats:bold>+<\/jats:bold><\/jats:sup>\u2010sulfhydryl compounds. Metallothionein protein (MT), induced by the accumulation of Hg<jats:sup>2<jats:bold>+<\/jats:bold><\/jats:sup> in the kidneys, may play an important role in detoxication after it forms a non\u2010toxic Hg<jats:sup>2<jats:bold>+<\/jats:bold><\/jats:sup>\u2010MT compound. Despite the deposition of mercury in the brain, compared with organic mercury, inorganic mercury did not seem to damage the neurons. Drugs such as chelating agents and corticosteroids appear to effectively decrease the inflammation and delay pulmonary fibrosis.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01032.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:14:37Z","timestamp":1047489277000},"page":"169-174","source":"Crossref","is-referenced-by-count":72,"title":["Acute inorganic mercury vapor inhalation poisoning"],"prefix":"10.1111","volume":"50","author":[{"given":"Sigeyuki","family":"Asano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komyo","family":"Eto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Kurisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Gunji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hiraiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Hasuike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"71","volume-title":"Toxicology Today: Science of Body Protection from Toxicity.","author":"Sato H","year":"1994"},{"key":"e_1_2_9_3_2","first-page":"259","volume-title":"Toxicology Today: Science of Body Protection from Toxicity.","author":"Sato H","year":"1994"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1938.02790050015005"},{"key":"e_1_2_9_5_2","first-page":"59","article-title":"Accumulation of mercury in the brains of two autopsy cases with chronic inorganic mercury poisoning.","volume":"24","author":"Takahata N","year":"1970","journal-title":"Folia Psychiatr. 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