{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:46:32Z","timestamp":1761806792173},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>A case of primary T\u2010cell lymphoma of the appendix in an 84\u2010year\u2010old female was reported. Appendectomy was performed as a result of the clinical diagnosis of acute appendicitis, due to the rebound tenderness of McBurney\u2019s point and thickness of the appendix wall as determined from ultra echo sonograph. Grossly, the surgical resected appendix did not have a dominant inflammatory appearance, therefore a tumor was suspected. Microscopic examination showed diffused proliferation of large and medium size lymphoma cells. Immunohistochemical examination further revealed that the lymphoma cells were positive for T\u2010cell markers. To ensure this was a T\u2010cell lymphoma, molecular examination was performed using paraffin\u2010embedded tissue sections, since T\u2010cell lymphoma of the appendix is extremely rare. Polymerase chain reaction (PCR) single\u2010strand conformation polymorphism (SSCP) analysis demonstrated monoclonal T\u2010cell receptor gene rearrangement. T\u2010cell\u2010rich B\u2010cell lymphoma was excluded. To our knowledge, this is the first reported case of primary T\u2010cell lymphoma of the appendix. PCR\u2010SSCP analysis in paraffin\u2010embedded tissue section was very useful in the diagnosis of lymphoma cell monoclonality.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01037.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:14:23Z","timestamp":1047489263000},"page":"313-317","source":"Crossref","is-referenced-by-count":19,"title":["Primary T\u2010cell non\u2010Hodgkin\u2019s malignant lymphoma of the appendix"],"prefix":"10.1111","volume":"50","author":[{"given":"Yukisato","family":"Kitamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<693::AID-CNCR2820420241>3.0.CO;2-J"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.8.1673"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-7404(94)90040-X"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880415)61:8<1602::AID-CNCR2820610818>3.0.CO;2-P"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00713283"},{"key":"e_1_2_7_7_2","first-page":"1841","article-title":"Detection of clonal immunoglobulin gene rearrangements by polymerase chain reaction amplification and single\u2010strand conformational polymorphism.","volume":"142","author":"Davis TH","year":"1993","journal-title":"Am. 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