{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:19:18Z","timestamp":1790936358597,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>An Epstein\u2013Barr virus\u2010transformed B\u2010cell line, HBM\u2010Noda (Noda), that has a dendritic morphology as well as several characteristic features of dendritic cells (DC) has been established. We therefore refer to Noda as B\u2010lineage DC. Although human T\u2010cell leukemia\/lymphoma virus type I (HTLV\u2010I) exhibit substantial cellular tropism, the roles of DC in HTLV\u2010I infection remain unknown. To further clarify the characteristics of Noda cells, we performed infection experiments using a concentrated HTLV\u2010I fraction from the adult T\u2010cell leukemia cell line, HPB\u2010ATL\u20102. Noda, as well as other cell lines examined, were sensitive to HTLV\u2010I infection as detected by proviral DNA using polymerase chain reaction, but most infected Noda cells underwent necrosis within 7 days. The most striking feature of Noda cells was the abundant expression of viral antigen (p19) on the cell surface following infection (approximately day 4), probably due to strong viral adsorption. In cocultivation experiments using Noda cells at day 1 of post\u2010infection and peripheral blood activated T cells, we detected a few (1.3%) viral antigen expressing T cells after 5 days of coculture by flow cytometry. These results suggest that B\u2010lineage DC such as Noda cells play a role in the establishment of HTLV\u2010I infection at an early phase.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01040.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:14:23Z","timestamp":1047489263000},"page":"280-290","source":"Crossref","is-referenced-by-count":6,"title":["A human B\u2010lineage dendritic cell line, HBM\u2010Noda and its potential role in human T\u2010cell leukemia\/lymphoma virus type I infection"],"prefix":"10.1111","volume":"50","author":[{"given":"Makoto","family":"Nagasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Torii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80153-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199801000-00002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.6.795"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.4049\/jimmunol.128.4.1764","article-title":"Antigen presentation by normal B cells, B cell tumors, and macrophages: Functional and biochemical comparison.","volume":"128","author":"Chesnut RW","year":"1982","journal-title":"J. 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