{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:04:31Z","timestamp":1776323071852,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>Kaposi\u2019s sarcoma occurring in a 78\u2010year\u2010old woman, with the absence of the human immunodeficiency virus infection, was correctly diagnosed by immunohistochemistry using anti\u2010human herpesvirus 8 (HHV8) antibody (PA1\u201073N) for the first time. The patient suffered from chronic respiratory failure and was treated with a low dose of steroids for 2.5 years. After her medication dosage was increased for the exacerbation of the respiratory failure, multiple skin tumors in her feet and legs suddenly developed. Histopathologically, skin tumors were suspected as Kaposi\u2019s sarcoma at the first biopsy and reactive angiomatosis at the second biopsy. Polymerase chain reaction and immunohistochemistry, however, revealed the presence of HHV8 DNA fragment and positive staining in the majority of spindle cells in the skin tumors. Serological examination confirmed the positivity of anti\u2010HHV8 antibodies. HHV8 infection and steroid\u2010induced immunosuppression, as well as environmental factors played a role in the development of Kaposi\u2019s sarcoma in this patient, because she was born in Okinawa, which is a well\u2010known endemic area of Kaposi\u2019s sarcoma in Japan. As her general condition improved, the skin lesions regressed without any specific treatment, and disappeared completely 8 months later, in which regression may be associated with evidence of numerous CD8 cell infiltration in the second biopsy tissues. No recurrence was observed during the following 6 month follow up.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01043.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:14:23Z","timestamp":1047489263000},"page":"340-346","source":"Crossref","is-referenced-by-count":14,"title":["Spontaneously regressed Kaposi\u2019s sarcoma and human herpesvirus 8 infection in a human immunodeficiency virus\u2010negative patient"],"prefix":"10.1111","volume":"50","author":[{"given":"Yasuko","family":"Kondo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Yanagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harutaka","family":"Katano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsutaro","family":"Sata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"5","article-title":"Epidemiology of Kaposi\u2019s sarcoma.","volume":"10","author":"Beral V.","year":"1991","journal-title":"Cancer Surv."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90641-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906173402410"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70146-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920815)70:4<861::AID-CNCR2820700423>3.0.CO;2-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1115.x"},{"key":"e_1_2_6_9_2","first-page":"72","article-title":"Diagnostic implication of Kaposi\u2019s sarcoma\u2010associated herpesvirus with special reference to the distribution between spindle cell hemangioendothelioma and Kaposi\u2019s sarcoma.","volume":"122","author":"Hisaoka M","year":"1998","journal-title":"Arch. 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