{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:06:40Z","timestamp":1763035600921},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":511,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>Formalin\u2010fixed paraffin\u2010embedded sections of three cases of ameloblastic fibrodentinoma (AFD) were studied by the avidin\u2013biotin\u2013peroxidase complex method using antibodies against neuron\u2010specific enolase (NSE), glial fibrillary acidic protein (GFAP) and S100 protein and the results were compared with those in ameloblastic fibroma (AF). A striking histopathological characteristic of AFD was the formation of abortive dentin with various degrees of maturation at the epithelial\u2013mesenchymal tissue interface. Central cells of enamel organ\u2010like epithelia with various stages of abortive dentin induction in AFD were generally positive for NSE. Dental lamina\u2010like epithelial cells also showed positive staining in some areas. No cells were positive for NSE in AF. Positive staining for GFAP was observed in the juxta\u2010epithelial mesenchymal tissue of the formation stage of immature dentin with various numbers of entrapped cells in AFD, but GFAP staining was negative in other mesenchymal and epithelial tissues at other stages. In AF, no GFAP\u2010positive cells were found. There were a few S100 protein\u2010positive cells found in the foci of epithelial components in both AFD and AF. Mesenchymal cells showing a dendritic or spindle shape were positive for S100 protein in some areas of AFD and AF. Although such cells in the mesenchymal component of pigmented AFD were more numerous than in non\u2010pigmented AFD and AF, their distribution pattern in the former condition was basically similar to that in the latter. Although the present results, obtained from conventional immunohistochemical procedures, do not directly reflect the expression of neural crest\u2010derived cells in the dentinogenesis of AFD, such results do not disprove the possibility of the expression of neural proteins probably related to neural crest\u2010derived cells in dentinogenesis under certain pathologic conditions in odontogenic mixed tumors. Such a phenomenon may also occur during dentinogenesis in other odontogenic mixed tumors and in normal tooth differentiation, but at an undetectable level.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01087.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:15:18Z","timestamp":1047489318000},"page":"610-615","source":"Crossref","is-referenced-by-count":17,"title":["Immunohistochemical expression of neural tissue markers (neuron\u2010specific enolase, glial fibrillary acidic protein, S100 protein) in ameloblastic fibrodentinoma: A comparative study with ameloblastic fibroma"],"prefix":"10.1111","volume":"50","author":[{"given":"Yasunori","family":"Takeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02858-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90132-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1982.tb01206.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1984.tb01398.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1984.tb01404.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1242\/dev.101.2.289","article-title":"Changes in the distribution of tenascin during tooth development.","volume":"101","author":"Thesleff I","year":"1987","journal-title":"Development"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1988.tb01521.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb00395.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890411"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(94)00046-7"},{"key":"e_1_2_6_12_2","volume-title":"Oral Histology","author":"Ten Cate AR.","year":"1989"},{"key":"e_1_2_6_13_2","first-page":"980","article-title":"S\u2010100 protein immunostaining in teratomatous well\u2010differentiated tissue.","volume":"11","author":"Carbone A","year":"1987","journal-title":"Histopathology"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(93)90174-K"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb00200.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(81)90056-6"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1983.tb00314.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890100508"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1994.tb00264.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-1955(96)00067-X"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00039-1"},{"key":"e_1_2_6_22_2","first-page":"554","article-title":"Expression of gamma\u2010subunit of enolase, neuron\u2010specific enolase, in human non\u2010neuroendocrine tumors and derived cell lines.","volume":"54","author":"Pahlman S","year":"1986","journal-title":"Lab. Invest."},{"key":"e_1_2_6_23_2","first-page":"796","article-title":"Recent applications of immunoperoxidase histochemistry in human neuro\u2010oncology.","volume":"111","author":"Perentes E","year":"1987","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_6_24_2","first-page":"258","article-title":"Immunohistochemical characterization of a set of monoclonal antibodies to human neuron\u2010specific enolase.","volume":"131","author":"Seshi B","year":"1988","journal-title":"Am. J. Pathol."},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(80)80273-1"},{"key":"e_1_2_6_26_2","first-page":"309","article-title":"Immunohistochemistry of nervous system antigen. Diagnostic applications in surgical neuropathology.","volume":"1","author":"Clark HB.","year":"1984","journal-title":"Semin. Diagn. Pathol."},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)81170-2"},{"key":"e_1_2_6_28_2","first-page":"261","volume-title":"Developmental and Evolutionary Aspects of the Neural Crest","author":"Lumsden AGS.","year":"1987"},{"key":"e_1_2_6_29_2","first-page":"223","article-title":"Role of the early epithelium in the patterning of the teeth and Meckel's cartilage.","volume":"11","author":"Koller EJ","year":"1991","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"e_1_2_6_30_2","first-page":"338","article-title":"Molecular determinants during dental morphogenesis and cytodifferentiation: A review.","volume":"11","author":"Slavkin HC.","year":"1991","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050962"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1998.tb02157.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00718652"},{"key":"e_1_2_6_34_2","doi-asserted-by":"crossref","unstructured":"TakedaY SatoH SatohM NakamuraS YamamotoH.Pigmented ameloblastic fibrodentinoma a novel melanin\u2010pigmented intraosseous odontogenic lesion.Virchows Arch2000(in press).","DOI":"10.1007\/s004280000249"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1440-1827.2000.01087.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1440-1827.2000.01087.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T12:39:42Z","timestamp":1698583182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1440-1827.2000.01087.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1046\/j.1440-1827.2000.01087.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1827.2000.01087.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}