{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:53:50Z","timestamp":1791118430753,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":480,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>New insights into the immunology and genetics of malignant lymphomas have allowed the recognition of new entities and the refinement of previously recognized disease categories. The relative incidence of these subtypes of malignant lymphoma is also known to differ according to geographic location. In order to clarify the current status of malignant lymphomas in Japan and the relative incidences of their subtypes, 3194 patients were classified according to the new World Health Organization (WHO) classification. Among these were 3025 cases (94.71%) of non\u2010Hodgkin's lymphoma (2189 cases (68.53%) of B\u2010cell lymphoma, 796 cases (24.92%) of T\u2010cell lymphoma) and 141 cases (4.41%) of Hodgkin's lymphoma. The incidences of the major subtypes of non\u2010Hodgkin's lymphoma were 33.34% for diffuse large B\u2010cell lymphoma, 8.45% for marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue (MALT) type, 8.05% for plasma cell myeloma, 7.45% for adult T\u2010cell leukemia\/lymphoma (ATLL), 6.7% for follicular lymphoma, 6.67% for peripheral T\u2010cell lymphoma of unspecified type, 2.79% for mantle cell lymphoma, 2.6% for nasal and nasal\u2010type T\/NK cell lymphoma, 2.35% for angioimmunoblastic T\u2010cell lymphoma, and 2.35% for precursor B\u2010cell lymphoblastic leukemia\/lymphoma, in decreasing order. The other subtypes comprised less than 2%, mainly precursor T\u2010cell lymphoblastic lymphoma\/leukemia (1.72%), anaplastic large\u2010cell lymphoma of T\u2010 and null\u2010cell types (1.53%), and B\u2010cell chronic lymphocytic leukemia\/small lymphocytic lymphoma (1.31%). The incidence of ATLL was influenced by its high percentage (19.20%) in the south\u2010western Japanese island, Kyushu, an endemic area of human T\u2010cell leukemia virus type 1 (HTLV\u20101), but which appeared to be lower than that in a previous study. The nodular sclerosis and mixed cellularity types of Hodgkin's disease occupied 1.78% and 1.63%, respectively. These data are distinct from those in Western countries and similar in several ways to those in the East, although the relatively high rate of ATLL was attributed to the geographical difference in the etiologic factor, HTLV\u20101.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01108.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T12:15:36Z","timestamp":1047471336000},"page":"696-702","source":"Crossref","is-referenced-by-count":337,"title":["The World Health Organization classification of malignant lymphomas in Japan: Incidence of recently recognized entities"],"prefix":"10.1111","volume":"50","author":[{"given":"*Lymphoma Study Group of Japanese","family":"Pathologists","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-97187-7"},{"key":"e_1_2_5_5_2","first-page":"109","article-title":"Hematopathology: Integration of morphologic features and biologic markers for diagnosis.","volume":"12","author":"Jaffe ES.","year":"1999","journal-title":"Mod. 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