{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:12:06Z","timestamp":1768619526695,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":450,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>A case of alpha\u2010fetoprotein (AFP) producing endometrial carcinoma in a 60\u2010year\u2010old Japanese woman is presented. The patient complained of abnormal vaginal bleeding of 10 days\u2019 duration. On admission a uterine corpus mass and high serum AFP concentration (31950 ng\/mL) was noted. There was no tumorous lesion in any other organ radiographically and endoscopically. Histologically, the biopsy specimen taken from the uterine mass showed a poorly differentiated endometrial carcinoma and a radical hysterectomy was subsequently performed. The postoperative serum AFP value transiently decreased with chemotherapy, however, lung metastases were found and the patient died 12 months following surgery. The resected uterus had a necrotic tumor, 6 \u00d7 5 \u00d7 4 cm in size, filling the endometrial cavity, characterized by exophytic growth with infiltration in the myometrium. Histologically, the tumor was composed of the main medullary carcinoma area with microcysts and admixed small areas of well\u2010differentiated endometrioid adenocarcinoma, accompanied by a smooth transition with one another. In both the areas, the tumor cells had immunoreactive AFP, alpha\u20101\u2010antitripsin, albumin, transferrin, carcinoembryonic antigen, CA19\u20109, and epithelial membrane antigen. There was no histologic evidence for a germ cell tumor. Based on these findings, this uterine corpus tumor was regarded as hepatoid variant of endometrial carcinoma. Although the histogenesis remains controversial, we assume the hypothesis that the tumor may arise in the endometrium <jats:italic>per se<\/jats:italic> in association with abnormal differentiation of muellerian duct elements.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2000.01124.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:13:58Z","timestamp":1047489238000},"page":"847-852","source":"Crossref","is-referenced-by-count":39,"title":["Alpha\u2010fetoprotein producing uterine corpus carcinoma: A hepatoid adenocarcinoma of the endometrium"],"prefix":"10.1111","volume":"50","author":[{"given":"Hiroshi","family":"Toyoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111042851907"},{"key":"e_1_2_6_3_2","first-page":"149","article-title":"Serum 2\u2010fetoprotein\u2010positive stomach cancer\u2010fetoprotein and hepatoma.","volume":"14","author":"Akai S","year":"1973","journal-title":"Gann Monograph Cancer Res."},{"key":"e_1_2_6_4_2","first-page":"991","article-title":"Serum \u03b1\u2010fetoprotein in patients with neoplasms of the gastrointestinal tract.","volume":"35","author":"McIntire KR","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871201)60:11<2775::AID-CNCR2820601130>3.0.CO;2-S"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF02924151","article-title":"Alpha\u2010fetoprotein positive adenocarcinoma of the pancreas.","volume":"4","author":"Scheithauer W","year":"1989","journal-title":"Int. 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