{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:40:40Z","timestamp":1694464840529},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2713,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>A 60\u2010year\u2010old woman presented with a history of palpitations, headaches and severe hypertension, which was resistant to hypotensive agents. She had a 2\u2010year history of obesity and a moon face. Her plasma adrenocorticotropic hormone level was below the limits of detection and did not respond to corticotropin\u2010releasing hormone. Urinary\u2010free cortisol was elevated and the circadian rhythm of serum cortisol level had completely disappeared. Imaging analysis demonstrated a unilaterally functioning mass in the left adrenal gland. Serum cortisol level in the left adrenal vein was elevated. The resected adrenal mass measured 4 \u00d7 3.5 \u00d7 2.5 cm, and ranged from yellow to tan in color. The adrenal cortex adjacent to the nodule did not demonstrate cortical atrophy. The mass was well circumscribed but not encapsulated, and consisted of multiple cortical nodules. These nodules were composed predominantly of clear cortical cells, and partly of compact cortical cells. Immunoreactivity of steroidogenic enzymes including cholesterol side\u2010chain\u2010cleavage P450, 3\u03b2\u2010hydroxysteroid dehydrogenase, 21\u2010hydroxylase cytochrome P450, 11\u03b2\u2010hydroxylase cytochrome P450 and 17\u03b1\u2010hydroxylase cytochrome P450 was marked in cortical nodules, but minimal in non\u2010nodular cortex. Ultrastructural examination of nodular cortical cells also demonstrated well\u2010developed mitochondria and smooth endoplasmic reticulum, consistent with elevated steroidogenesis in these cells.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2001.01169.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:16:13Z","timestamp":1047489373000},"page":"118-122","source":"Crossref","is-referenced-by-count":5,"title":["Adrenocorticotropin\u2010independent unilateral adrenocortical hyperplasia with Cushing's syndrome: Immunohistochemical studies of steroidogenic enzymes, ultrastructural examination and a review of the literature"],"prefix":"10.1111","volume":"51","author":[{"given":"Toshinari","family":"Takamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhisa","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken\u2010Ichi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0930495"},{"key":"e_1_2_5_3_2","first-page":"46","article-title":"Cushing's syndrome in unilateral diffuse\u2010nodular hyperplasia of the adrenal cortex with a corticosteroma and in combination with a pheochromocytoma.","volume":"35","author":"Bronshtein ME","year":"1986","journal-title":"Probl. 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