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Recently, we observed that this strain coincidentally developed atypical hyperplasia of the choledocho\u2010pancreatic ductal epithelium with a complete incidence. In an effort to locate genes responsible for this hyperplasia, we prepared 288 backcross progeny from a mating between OLETF rats and BN rats (which do not develop hyperplasia), and performed a genome\u2010wide scan using 207 polymorphic genetic markers. We observed a prominent association of hyperplasia with a region involving a marker locus <jats:italic>D14Mit4<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.00020, Fisher's exact test) and <jats:italic>Cckar<\/jats:italic> (the cholecystokinin\u2010A receptor gene; <jats:italic>P<\/jats:italic> = 0.00025, Fisher's exact test) which is known to be disrupted in an OLETF strain. Our findings indicated that epithelial hyperplasia of the choledocho\u2010pancreatic duct is associated with a region on rat chromosome 14 around the <jats:italic>Cckar<\/jats:italic> gene in an additive fashion with another two susceptible loci, each on chromosome 9 and 7. This implied the possibility that <jats:italic>Cckar<\/jats:italic> deficiency could result in a predisposition towards pancreatic duct hyperplasia.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2001.01176.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:16:14Z","timestamp":1047489374000},"page":"133-139","source":"Crossref","is-referenced-by-count":5,"title":["Genetic analysis of pancreatic duct hyperplasia in Otsuka Long\u2013Evans Tokushima Fatty rats: Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin\u2010A receptor gene"],"prefix":"10.1111","volume":"51","author":[{"given":"Naohide","family":"Kanemoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Iwanaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haretsugu","family":"Hishigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Mizoguchi\u2010Miyakita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Oga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi K.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tanigami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199804000-00005"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199804000-00006"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820137"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199603000-00007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/58.5.1449"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199804000-00015"},{"key":"e_1_2_6_8_2","first-page":"2249","article-title":"Adenocarcinoma of the pancreas in azaserine\u2010treated rats.","volume":"35","author":"Longnecker DS","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/8.12.1831"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/60.2.355"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312216"},{"key":"e_1_2_6_12_2","first-page":"24","article-title":"A new rat strain with non insulin dependent diabetes mellitus, \u2018OLETF\u2019.","volume":"25","author":"Kawano K","year":"1991","journal-title":"Rat News Lett."},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.11.1422"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050388"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01024.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900789"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5789"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.6018"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(97)00259-x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.5.434"},{"key":"e_1_2_6_21_2","unstructured":"The Whitehead Institute for Biochemical Research\/MIT Center for Genome Research map.http:\/\/www.genome.wi.mit.edu\/rat\/public\/"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/8737"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.1993.00739.x"},{"key":"e_1_2_6_24_2","volume-title":"MapQTL (tm) Version 3.0: Software for the calculation of QTL position on genetics maps","author":"Van Ooijan JW","year":"1996"},{"key":"e_1_2_6_25_2","first-page":"510","article-title":"Power and sample size in linkage studies.","volume":"37","author":"Kidd KK","year":"1984","journal-title":"Cytogenet. 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